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    Exosc2 exosome component 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366017, updated on 27-Nov-2024

    Summary

    Official Symbol
    Exosc2provided by RGD
    Official Full Name
    exosome component 2provided by RGD
    Primary source
    RGD:1306573
    See related
    EnsemblRapid:ENSRNOG00000009245 AllianceGenome:RGD:1306573
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA metabolic process and positive regulation of cell growth. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in short stature, hearing loss, retinitis pigmentosa, and distinctive facies. Orthologous to human EXOSC2 (exosome component 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 85.0), Spleen (RPKM 72.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Exosc2 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (35360652..35370948)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14962930..14973645)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (10151734..10161997, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene far upstream element binding protein 3 Neighboring gene PR/SET domain 12 Neighboring gene ABL proto-oncogene 1, non-receptor tyrosine kinase Neighboring gene uncharacterized LOC134486069 Neighboring gene pyroglutamylated RFamide peptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT enables RNA exonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in CUT catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TRAMP-dependent tRNA surveillance pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    exosome complex component RRP4
    Names
    exosome complex exonuclease RRP4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108952.1NP_001102422.1  exosome complex component RRP4

      See identical proteins and their annotated locations for NP_001102422.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474001
      UniProtKB/TrEMBL
      A6JU28, D3ZBP3
      Related
      ENSRNOP00000012311.3, ENSRNOT00000012312.8
      Conserved Domains (2) summary
      COG1097
      Location:22243
      Rrp4; Exosome complex RNA-binding protein Rrp4, contains S1 and KH domains [Translation, ribosomal structure and biogenesis]
      cd22525
      Location:169285
      KH-I_Rrp4_eukar; type I K homology (KH) RNA-binding domain found in exosome complex component Rrp4 from eukaryote

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      35360652..35370948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284261.1XP_063140331.1  exosome complex component RRP4 isoform X1

    2. XM_039105586.2XP_038961514.1  exosome complex component RRP4 isoform X2

      Conserved Domains (2) summary
      cd05789
      Location:254
      S1_Rrp4; Rrp4 S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Rrp4 protein is a subunit of the exosome complex. The exosome plays a central role in 3' to 5' RNA processing and degradation in ...
      cd22525
      Location:57173
      KH-I_Rrp4_eukar; type I K homology (KH) RNA-binding domain found in exosome complex component Rrp4 from eukaryote