Fahd2a fumarylacetoacetate hydrolase domain containing 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fahd2aprovided by RGD
Official Full Name: fumarylacetoacetate hydrolase domain containing 2Aprovided by RGD
Primary source: RGD:1563674
See related: EnsemblRapid:ENSRNOG00000013974 AllianceGenome:RGD:1563674
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fahd2; RGD1563674
Summary: Predicted to enable oxaloacetate tautomerase activity. Predicted to be involved in oxaloacetate metabolic process. Predicted to be located in mitochondrion. Orthologous to human FAHD2A (fumarylacetoacetate hydrolase domain containing 2A) and FAHD2B (fumarylacetoacetate hydrolase domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 512.7), Adrenal (RPKM 198.2) and 9 other tissues See more
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Genomic context

Location:: 3q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (135110480..135118653, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114657176..114665349, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (120003215..120011392, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxaloacetate tautomerase activity	IEA Inferred from Electronic Annotation more info
enables oxaloacetate tautomerase activity	ISO Inferred from Sequence Orthology more info
enables oxaloacetate tautomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in oxaloacetate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oxaloacetate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in oxaloacetate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oxaloacetate tautomerase Fahd2a, mitochondrial

Names: fumarylacetoacetate hydrolase domain-containing protein 2; fumarylacetoacetate hydrolase domain-containing protein 2A

NP_001128306.1

EC 5.3.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134834.2 → NP_001128306.1 oxaloacetate tautomerase Fahd2a, mitochondrial

See identical proteins and their annotated locations for NP_001128306.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

B2RYW9

UniProtKB/TrEMBL

A6HQ16

Related

ENSRNOP00000079379.1, ENSRNOT00000109233.2

Conserved Domains (2) summary

COG0179
Location:48 → 313

MhpD; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport and catabolism]

pfam01557
Location:109 → 312

FAA_hydrolase; Fumarylacetoacetate (FAA) hydrolase family