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    Jagn1 jagunal homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502872, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jagn1provided by RGD
    Official Full Name
    jagunal homolog 1provided by RGD
    Primary source
    RGD:1565488
    See related
    EnsemblRapid:ENSRNOG00000009175 AllianceGenome:RGD:1565488
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in severe congenital neutropenia 6. Orthologous to human JAGN1 (jagunal homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 155.9), Liver (RPKM 130.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Jagn1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148147213..148151915)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146591577..146596287)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145399885..145404605)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cell death-inducing DFFA-like effector c Neighboring gene apolipoprotein O, pseudogene 2 Neighboring gene U2 spliceosomal RNA Neighboring gene interleukin 17 receptor E Neighboring gene interleukin 17 receptor C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. JAGN1 Deficient Severe Congenital Neutropenia: Two Cases from the Same Family. Baris S, et al. J Clin Immunol, 2015 May. PMID 25851723
    2. JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia. Boztug K, et al. Nat Genet, 2014 Sep. PMID 25129144, Free PMC Article
    3. Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis. Nosak C, et al. PLoS One, 2016. PMID 26882284, Free PMC Article
    4. Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense. Wirnsberger G, et al. Nat Genet, 2014 Sep. PMID 25129145, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results identify a novel role for Jagn1 in regulating proinsulin biosynthesis.
      Title: Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112769

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in defense response to fungus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to fungus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in granulocyte colony-stimulating factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in granulocyte colony-stimulating factor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in granulocyte colony-stimulating factor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in neutrophil differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neutrophil mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil mediated immunity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neutrophil migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein jagunal homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044272.1 → NP_001037737.1  protein jagunal homolog 1

      See identical proteins and their annotated locations for NP_001037737.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098749
      UniProtKB/Swiss-Prot
      Q4KM64
      UniProtKB/TrEMBL
      A0A8I5ZXA3, A6IBS0
      Related
      ENSRNOP00000053385.2, ENSRNOT00000012177.7
      Conserved Domains (1) summary
      pfam07086
      Location:1 → 177
      Jagunal; ER re-organisation during oogenesis

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      148147213..148151915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237053.5 → XP_006237115.1  protein jagunal homolog 1 isoform X2

      Conserved Domains (1) summary
      pfam07086
      Location:1 → 29
      Jagunal; Jagunal, ER re-organization during oogenesis

    2. XM_063286616.1 → XP_063142686.1  protein jagunal homolog 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM64.1 GenPept UniProtKB/Swiss-Prot:Q4KM64

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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