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    Eno2 enolase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24334, updated on 9-Dec-2024

    Summary

    Symbol
    Eno2provided by RGD
    Full Name
    enolase 2provided by RGD
    Primary source
    RGD:2554
    See related
    EnsemblRapid:ENSRNOG00000013141 AllianceGenome:RGD:2554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NSE; RNEN3
    Summary
    Enables enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Involved in glucose metabolic process; response to estradiol; and response to xenobiotic stimulus. Located in several cellular components, including growth cone; membrane raft; and synaptic membrane. Part of phosphopyruvate hydratase complex. Biomarker of Parkinsonism; toxic shock syndrome; and visual epilepsy. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ENO2 (enolase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Note: LOC100911625 appears to be a duplicate placement of Eno2 (GeneID: 24334) on Rnor_6.0 (Annot. Release 105) that is absent from Rn_Celera and is not supported by syntenic regions in mouse and human. BLAST analysis of the underlying component AABR07066868.1 against the rat genome shows high sequence identity (88% coverage, 99% identity) with part of NC_005103.4 on which Eno2 is annotated. Annotation of Eno2 at this location on Rnor_6.0 is supported by annotation on Rn_Celera and synteny with mouse and human. [14 Apr 2021]
    Expression
    Biased expression in Brain (RPKM 1706.0) and Uterus (RPKM 89.6) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Eno2 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159258371..159267220, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157572085..157580971, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157285192..157294090, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene gene rich cluster, C10 gene Neighboring gene atrophin 1 Neighboring gene uncharacterized LOC120102384 Neighboring gene leucine rich repeat containing 23 Neighboring gene uncharacterized LOC134486638 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2 Neighboring gene triosephosphate isomerase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphopyruvate hydratase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphopyruvate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphopyruvate hydratase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in canonical glycolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in gluconeogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phosphopyruvate hydratase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor inner segment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in photoreceptor inner segment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-enolase
    Names
    2-phospho-D-glycerate hydro-lyase
    enolase 2, gamma, neuronal
    gamma-enolase-like
    neural enolase
    neuron-specific enolase
    NP_647541.1
    XP_006237392.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139325.4NP_647541.1  gamma-enolase

      See identical proteins and their annotated locations for NP_647541.1

      Status: VALIDATED

      Source sequence(s)
      CB615520, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P07323
      UniProtKB/TrEMBL
      A0A8L2Q2X9, A6ILK1
      Related
      ENSRNOP00000005601.5, ENSRNOT00000005601.6
      Conserved Domains (1) summary
      PLN00191
      Location:2432
      PLN00191; enolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      159258371..159267220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237330.5XP_006237392.1  gamma-enolase isoform X1

      See identical proteins and their annotated locations for XP_006237392.1

      UniProtKB/Swiss-Prot
      P07323
      UniProtKB/TrEMBL
      A0A8L2Q2X9, A6ILK1
      Conserved Domains (1) summary
      PLN00191
      Location:2432
      PLN00191; enolase