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    Plscr2 phospholipid scramblase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315883, updated on 3-Dec-2024

    Summary

    Official Symbol
    Plscr2provided by RGD
    Official Full Name
    phospholipid scramblase 2provided by RGD
    Primary source
    RGD:1359107
    See related
    EnsemblRapid:ENSRNOG00000064984 AllianceGenome:RGD:1359107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phospholipid scramblase activity. Predicted to be involved in cellular response to lipopolysaccharide and plasma membrane phospholipid scrambling. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 768.8), Lung (RPKM 219.4) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Plscr2 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (101689202..101725726)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (92809422..92845947)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (99650351..99725514)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094226 Neighboring gene uncharacterized LOC102550510 Neighboring gene phospholipid scramblase 1 Neighboring gene phospholipid scramblase 1 like 1 Neighboring gene uncharacterized LOC134480085 Neighboring gene phospholipid scramblase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipid scramblase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in plasma membrane phospholipid scrambling IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014094.2NP_001014116.1  phospholipid scramblase 2 isoform 1

      See identical proteins and their annotated locations for NP_001014116.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AEL2, Q6AYD7
      Related
      ENSRNOP00000091509.2, ENSRNOT00000116380.2
      Conserved Domains (2) summary
      pfam03803
      Location:88308
      Scramblase; Scramblase
      pfam11029
      Location:299
      DAZAP2; DAZ associated protein 2 (DAZAP2)
    2. NM_001423657.1NP_001410586.1  phospholipid scramblase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AEL2
      Related
      ENSRNOP00000086482.2, ENSRNOT00000108295.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      101689202..101725726
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081540.2XP_038937468.1  phospholipid scramblase 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JYB5, A0A8I6AEL2
      Conserved Domains (1) summary
      pfam03803
      Location:86306
      Scramblase
    2. XM_063265573.1XP_063121643.1  phospholipid scramblase 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AEL2
    3. XM_063265572.1XP_063121642.1  phospholipid scramblase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3V8, A0A8I6AEL2, A6I240
    4. XM_063265571.1XP_063121641.1  phospholipid scramblase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A3V8, A0A8I6AEL2, A6I240