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    PRECSIT p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcript [ Homo sapiens (human) ]

    Gene ID: 283487, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PRECSITprovided by HGNC
    Official Full Name
    p53 regulated carcinoma associated Stat3 activating long intergenic non-protein coding transcriptprovided by HGNC
    Primary source
    HGNC:HGNC:27492
    See related
    Ensembl:ENSG00000255874 AllianceGenome:HGNC:27492
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C13orf29; LINC00346; NCRNA00346
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    Genomic context

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    See PRECSIT in Genome Data Viewer
    Location:
    13q34
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (110863987..110870308, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (110094081..110100400, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111516334..111522655, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370362 Neighboring gene NANOG hESC enhancer GRCh37_chr13:111468190-111468713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5518 Neighboring gene uncharacterized LOC105370363 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111502835-111503338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111503339-111503840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111505979-111506517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5519 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:111521756-111522955 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111525201-111526078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5520 Neighboring gene ankyrin repeat domain 10 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111558775-111559276 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:111560595-111561212 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111566028-111566704 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5522 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:111568056-111568730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111581847-111582346 Neighboring gene poly(ADP-ribose) polymerase 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma. Zeng WJ, et al. Front Immunol, 2022. PMID 36311792, Free PMC Article
    2. p53-Regulated Long Noncoding RNA PRECSIT Promotes Progression of Cutaneous Squamous Cell Carcinoma via STAT3 Signaling. Piipponen M, et al. Am J Pathol, 2020 Feb. PMID 31837949
    3. A positive feedback loop involving the LINC00346/β-catenin/MYC axis promotes hepatocellular carcinoma development. Zhang N, et al. Cell Oncol (Dordr), 2020 Feb. PMID 31691159
    4. LINC00346 promotes hepatocellular carcinoma progression via activating the JAK-STAT3 signaling pathway. Yin YZ, et al. J Cell Biochem, 2020 Jan. PMID 31478228
    5. Long non-coding RNA LINC00346 promotes pancreatic cancer growth and gemcitabine resistance by sponging miR-188-3p to derepress BRD4 expression. Shi W, et al. J Exp Clin Cancer Res, 2019 Feb 6. PMID 30728036, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma.
      Title: A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma.
    2. Aberrant expression of LINC00346 regulates cell migration and proliferation via competitively binding to miRNA-148a-3p/Dnmt1 in Hirschsprung's disease.
      Title: Aberrant expression of LINC00346 regulates cell migration and proliferation via competitively binding to miRNA-148a-3p/Dnmt1 in Hirschsprung's disease.
    3. Upregulation of VDR-associated lncRNAs in Schizophrenia.
      Title: Upregulation of VDR-associated lncRNAs in Schizophrenia.
    4. Long non-coding RNA LINC00346 regulates proliferation and apoptosis by targeting miR-128-3p/SZRD1 axis in glioma.
      Title: Long non-coding RNA LINC00346 regulates proliferation and apoptosis by targeting miR-128-3p/SZRD1 axis in glioma.
    5. LINC00346 promotes hepatocellular carcinoma progression via activating the JAK-STAT3 signaling pathway.
      Title: LINC00346 promotes hepatocellular carcinoma progression via activating the JAK-STAT3 signaling pathway.
    6. A positive feedback loop involving the LINC00346/beta-catenin/MYC axis promotes hepatocellular carcinoma development.
      Title: A positive feedback loop involving the LINC00346/β-catenin/MYC axis promotes hepatocellular carcinoma development.
    7. High PRECSIT expression promotes Progression of Cutaneous Squamous Cell Carcinoma via STAT3 Signaling.
      Title: p53-Regulated Long Noncoding RNA PRECSIT Promotes Progression of Cutaneous Squamous Cell Carcinoma via STAT3 Signaling.
    8. LINC00346 shows the ability to promote pancreatic cancer growth and gemcitabine resistance, which is in part mediated by antagonization of miR-188-3p and induction of BRD4. Targeting LINC00346 may improve gemcitabine-based therapeutic efficacy.
      Title: Long non-coding RNA LINC00346 promotes pancreatic cancer growth and gemcitabine resistance by sponging miR-188-3p to derepress BRD4 expression.
    9. The interference in LINC 00346 expression could inhibit the in vivo tumorigenic ability of tumor cells through regulating the Janus kinase/signal transducer and activator of transcription 3 (JAK-STAT3) signaling pathway.
      Title: Up-regulation of LINC00346 inhibits proliferation of non-small cell lung cancer cells through mediating JAK-STAT3 signaling pathway.
    10. We found that linc00346 was upregulated in bladder cancer tissues compared to normal tissues. Knockdown of linc00346 inhibited bladder cancer cell proliferation and migration, induced cell cycle arrest and cell apoptosis. CONCLUSION: Our study demonstrates that linc00346 could be a potential oncogene and a therapeutic target in bladder cancer.
      Title: Long noncoding RNA linc00346 promotes the malignant phenotypes of bladder cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • long intergenic non-protein coding RNA 346

    Clone Names

    • FLJ97904

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027701.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AJ295981, AL157875, BX647632
      Related
      ENST00000538077.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      110863987..110870308 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      110094081..110100400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178514.3: Suppressed sequence

      Description
      NM_178514.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials