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    Endou endonuclease, polyU-specific [ Mus musculus (house mouse) ]

    Gene ID: 19011, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Endouprovided by MGI
    Official Full Name
    endonuclease, polyU-specificprovided by MGI
    Primary source
    MGI:MGI:97746
    See related
    Ensembl:ENSMUSG00000022468 AllianceGenome:MGI:97746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp11r; Tcl-30
    Summary
    Predicted to enable RNA binding activity; RNA endonuclease activity; and serine-type peptidase activity. Predicted to be involved in several processes, including female pregnancy; negative regulation of lipid catabolic process; and post-transcriptional gene silencing. Predicted to be located in cytoplasm. Is expressed in ileum; labyrinthine zone; and metanephros. Orthologous to human ENDOU (endonuclease, poly(U) specific). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 54.3) and lung adult (RPKM 2.5) See more
    Orthologs
    human all
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    Genomic context

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    See Endou in Genome Data Viewer
    Location:
    15 F1; 15 53.7 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97608896..97629286, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (97711015..97731405, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41394 Neighboring gene STARR-positive B cell enhancer ABC_E10876 Neighboring gene RNA polymerase II associated protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E7415 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97551732-97551973 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97561501-97561858 Neighboring gene STARR-positive B cell enhancer ABC_E5512 Neighboring gene STARR-positive B cell enhancer ABC_E2450 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97580414-97580523 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3 Neighboring gene predicted gene, 33531 Neighboring gene STARR-seq mESC enhancer starr_39638 Neighboring gene STARR-positive B cell enhancer ABC_E5513 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 3, opposite strand 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tcl-30, a new T cell-specific gene expressed in immature glucocorticoid-sensitive thymocytes. Baughman G, et al. J Immunol, 1992 Sep 1. PMID 1506680
    2. EndoU is a novel regulator of AICD during peripheral B cell selection. Poe JC, et al. J Exp Med, 2014 Jan 13. PMID 24344237, Free PMC Article
    3. Genetic mapping of Pp11r, a thymocyte gene expressed during apoptosis, to mouse chromosome 15. Kingsmore SF, et al. Mamm Genome, 1993. PMID 8104059
    4. Genes newly identified as regulated by glucocorticoids in murine thymocytes. Baughman G, et al. Mol Endocrinol, 1991 May. PMID 2072923
    5. The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Paikari A, et al. Development, 2017 Oct 15. PMID 28935707, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA endonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in female pregnancy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in post-transcriptional gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-transcriptional gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uridylate-specific endoribonuclease
    Names
    PP11-related protein
    T-cell-specific protein 30
    placental protein 11 related
    placental protein 11-related protein
    poly(U)-specific endoribonuclease
    protein endoU

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168693.1 → NP_001162164.1  uridylate-specific endoribonuclease isoform 2 precursor

      See identical proteins and their annotated locations for NP_001162164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains different segments for its 5' UTR and coding region, compared to variant 1. The predicted protein (isoform 2) results from translation initiation at an upstream AUG and has a shorter N-terminus, when it is compared to isoform 1.
      Source sequence(s)
      AA119943, AC104225, AK132616
      Consensus CDS
      CCDS49712.1
      UniProtKB/Swiss-Prot
      Q01084, Q3V188
      Related
      ENSMUSP00000097820.3, ENSMUST00000100249.10
      Conserved Domains (2) summary
      pfam01033
      Location:22 → 60
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:140 → 406
      XendoU; Endoribonuclease XendoU

    2. NM_008902.3 → NP_032928.1  uridylate-specific endoribonuclease isoform 1

      See identical proteins and their annotated locations for NP_032928.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC104225
      Consensus CDS
      CCDS27783.1
      UniProtKB/Swiss-Prot
      Q3V188
      Related
      ENSMUSP00000023105.4, ENSMUST00000023105.5
      Conserved Domains (2) summary
      pfam01033
      Location:130 → 167
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:182 → 448
      XendoU; Endoribonuclease XendoU

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      97608896..97629286 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520618.2 → XP_006520681.1  uridylate-specific endoribonuclease isoform X2

      Conserved Domains (2) summary
      pfam01033
      Location:6 → 44
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:124 → 390
      XendoU; Endoribonuclease XendoU

    2. XM_006520617.4 → XP_006520680.2  uridylate-specific endoribonuclease isoform X1

      Conserved Domains (2) summary
      pfam01033
      Location:46 → 84
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:164 → 430
      XendoU; Endoribonuclease XendoU

    3. XM_017316511.1 → XP_017172000.1  uridylate-specific endoribonuclease isoform X3

      Conserved Domains (2) summary
      pfam01033
      Location:34 → 71
      Somatomedin_B; Somatomedin B domain
      pfam09412
      Location:86 → 352
      XendoU; Endoribonuclease XendoU
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V188.1 GenPept UniProtKB/Swiss-Prot:Q3V188

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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