YBT1 bile acid-transporting ATPase YBT1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YBT1
Official Full Name: bile acid-transporting ATPase YBT1
Primary source: SGD:S000003971
Locus tag: YLL048C
See related: AllianceGenome:SGD:S000003971; FungiDB:YLL048C; VEuPathDB:YLL048C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BAT1
Summary: Enables ATPase-coupled monocarboxylic acid transmembrane transporter activity. Involved in monocarboxylic acid transport. Located in fungal-type vacuole membrane and membrane raft. Human ortholog(s) of this gene implicated in several diseases, including dilated cardiomyopathy (multiple); familial atrial fibrillation; glucose metabolism disease (multiple); hypertrichotic osteochondrodysplasia Cantu type; and intellectual disability and myopathy syndrome. Orthologous to human ABCC10 (ATP binding cassette subfamily C member 10); ABCC8 (ATP binding cassette subfamily C member 8); and ABCC9 (ATP binding cassette subfamily C member 9). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See YBT1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (41280..46265, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of YBT1 enhances in vitro homotypic vacuole fusion by up to 50% relative to wild-type vacuoles.
Title: The yeast vacuolar ABC transporter Ybt1p regulates membrane fusion through Ca2+ transport modulation.
Data show that Ybt1 is required to import the phosphatidylcholine (PC) analog NBD-PC (7-nitro-2,1,3-benzoxadiazol-PC) into vacuoles in the presence of ATP in vitro.
Title: Vacuolar import of phosphatidylcholine requires the ATP-binding cassette transporter Ybt1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled monocarboxylic acid transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in monocarboxylic acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
is_active_in fungal-type vacuole membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bile acid-transporting ATPase YBT1

NP_013052.1

Transporter of ATP-binding cassette (ABC) family; targeted to vacuole via AP-3 pathway; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

41280..46265 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181868.1 → NP_013052.1 TPA: bile acid-transporting ATPase YBT1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013052.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXW0, P32386, Q07882

UniProtKB/TrEMBL

C7GNE7

Conserved Domains (1) summary

TIGR00957
Location:353 → 1639

MRP_assoc_pro; multi drug resistance-associated protein (MRP)