SNC1 SNAP receptor SNC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNC1
Official Full Name: SNAP receptor SNC1
Primary source: SGD:S000000028
Locus tag: YAL030W
See related: AllianceGenome:SGD:S000000028; FungiDB:YAL030W; VEuPathDB:YAL030W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables SNAP receptor activity. Involved in several processes, including Golgi to plasma membrane transport; exocytosis; and vesicle fusion. Located in several cellular components, including cellular bud neck; cytoplasmic vesicle; and trans-Golgi network. Part of SNARE complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome and spastic ataxia 1. Orthologous to several human genes including VAMP4 (vesicle associated membrane protein 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SNC1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 2

Sequence:: Chromosome: I; NC_001133.9 (87286..87752)

Chromosome I - NC_001133.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001133.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myosin V-mediated transport of Snc1 and Vps10 toward the trans-Golgi network.
Title: Myosin V-mediated transport of Snc1 and Vps10 toward the trans-Golgi network.
Yeast synaptobrevin, Snc1, engages distinct routes of postendocytic recycling mediated by a sorting nexin, Rcy1-COPI, and retromer.
Title: Yeast synaptobrevin, Snc1, engages distinct routes of postendocytic recycling mediated by a sorting nexin, Rcy1-COPI, and retromer.
These results indicate that ubiquitination, a modification well known to target membrane proteins to the lysosome or vacuole for degradation, can also function as recycling signal to sort a SNARE into COPI vesicles in a non-degradative pathway.
Title: COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal.
The replacement of these residues led to severe defects in endosome-to-TGN transport of Snc1, providing evidence of the physiological relevance of the interaction of Vps51 with Vps1 for the traffic. Furthermore, our functional analysis revealed that Vps1 acts upstream of Vps51 and that the absence of Vps1 resulted in reduced localization levels of Vps51 and its binding partner Tlg1 to the late Golgi.
Title: Yeast dynamin associates with the GARP tethering complex for endosome-to-Golgi traffic.
Mutagenesis experiments suggest that the water-filled cavities contribute to the lower stability of the Saccharomyces cerevisiae complex.
Title: The structure of the yeast plasma membrane SNARE complex reveals destabilizing water-filled cavities.
Results indicate that retrograde trafficking of Snc1 from the endosome is essential for sporulation by retrieving molecules important for PSM and spore wall formation.
Title: Snc1p v-SNARE transport to the prospore membrane during yeast sporulation is dependent on endosomal retrieval pathways.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables SNAP receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables SNAP receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle fusion	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SNARE complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SNARE complex	IDA Inferred from Direct Assay more info	PubMed
part_of SNARE complex	IEA Inferred from Electronic Annotation more info
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in cell periphery	HDA more info	PubMed
located_in cellular bud	HDA more info	PubMed
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SNAP receptor SNC1

NP_009372.1

Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001133.9 Reference assembly

Range

87286..87752

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178175.1 → NP_009372.1 TPA: SNAP receptor SNC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009372.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VPI8, P31109

UniProtKB/TrEMBL

A7A0D8, B3LUW4, C7GPK5, C8Z3H2, G2W8K2, N1P8W0

Conserved Domains (1) summary

COG5143
Location:1 → 117

SNC1; Synaptobrevin/VAMP-like protein [Intracellular trafficking and secretion]