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    PTA1 RNA-processing protein PTA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851255, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PTA1
    Official Full Name
    RNA-processing protein PTA1
    Primary source
    SGD:S000000041
    Locus tag
    YAL043C
    See related
    AllianceGenome:SGD:S000000041; FungiDB:YAL043C; VEuPathDB:YAL043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN39
    Summary
    Predicted to contribute to RNA binding activity. Involved in tRNA processing and termination of RNA polymerase II transcription, poly(A)-coupled. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human SYMPK (symplekin scaffold protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PTA1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (58695..61052, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Bol1p Neighboring gene glycine decarboxylase subunit H Neighboring gene Erv46p Neighboring gene Rho family guanine nucleotide exchange factor CDC24

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PTA1, an essential gene of Saccharomyces cerevisiae affecting pre-tRNA processing. O'Connor JP, et al. Mol Cell Biol, 1992 Sep. PMID 1508188, Free PMC Article
    2. Involvement of Pta1, Pcf11 and a KlCYC1 AU-rich element in alternative RNA 3'-end processing selection in yeast. Seoane S, et al. FEBS Lett, 2009 Sep 3. PMID 19646984
    3. Functional interaction of the Ess1 prolyl isomerase with components of the RNA polymerase II initiation and termination machineries. Krishnamurthy S, et al. Mol Cell Biol, 2009 Jun. PMID 19332564, Free PMC Article
    4. Cleavage factor II of Saccharomyces cerevisiae contains homologues to subunits of the mammalian Cleavage/ polyadenylation specificity factor and exhibits sequence-specific, ATP-dependent interaction with precursor RNA. Zhao J, et al. J Biol Chem, 1997 Apr 18. PMID 9099738
    5. Ssu72 Is an RNA polymerase II CTD phosphatase. Krishnamurthy S, et al. Mol Cell, 2004 May 7. PMID 15125841

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data report the involvement of yeast RNA processing factors Pta1 and Pcf11 in alternative 3'-end RNA processing.
      Title: Involvement of Pta1, Pcf11 and a KlCYC1 AU-rich element in alternative RNA 3'-end processing selection in yeast.
    2. the amino terminus of Pta1 has an inhibitory effect and this effect can be neutralized through the interaction with Ssu72.
      Title: The essential N terminus of the Pta1 scaffold protein is required for snoRNA transcription termination and Ssu72 function but is dispensable for pre-mRNA 3'-end processing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase II transcription, poly(A)-coupled IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-processing protein PTA1
    NP_009356.1
    • Subunit of holo-CPF; holo-CPF is a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      58695..61052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178188.1 → NP_009356.1  TPA: RNA-processing protein PTA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009356.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPH3, Q01329
      UniProtKB/TrEMBL
      A7A0C3, G2W8I7, N1P9S4
      Conserved Domains (1) summary
      pfam11935
      Location:91 → 328
      DUF3453; Domain of unknown function (DUF3453)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01329.1

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