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    CDC10 septin CDC10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850358, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CDC10
    Official Full Name
    septin CDC10
    Primary source
    SGD:S000000595
    Locus tag
    YCR002C
    See related
    AllianceGenome:SGD:S000000595; FungiDB:YCR002C; VEuPathDB:YCR002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activity; molecular adaptor activity; and phosphatidylinositol binding activity. A structural constituent of cytoskeleton. Involved in several processes, including exit from mitosis; mitotic cytokinesis; and septin ring assembly. Located in cytoskeleton; mating projection base; and prospore membrane. Part of septin complex. Human ortholog(s) of this gene implicated in brachial plexus neuritis; colorectal cancer; and spermatogenic failure 10. Orthologous to several human genes including SEPTIN3 (septin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CDC10 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (117380..118348, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein YmL32 Neighboring gene flavodoxin-like fold family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cell integrity and morphogenesis in a budding yeast septin mutant. Cid VJ, et al. Microbiology (Reading), 1998 Dec. PMID 9884239
    2. The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures. Gao L, et al. Mol Biol Cell, 2010 Apr 1. PMID 20147448, Free PMC Article
    3. Formation of septum-like structures at locations remote from the budding sites in cytokinesis-defective mutants of Saccharomyces cerevisiae. Slater ML, et al. J Bacteriol, 1985 May. PMID 3886632, Free PMC Article
    4. Spore germination in Saccharomyces cerevisiae: global gene expression patterns and cell cycle landmarks. Joseph-Strauss D, et al. Genome Biol, 2007. PMID 17999778, Free PMC Article
    5. Cell cycle control of septin ring dynamics in the budding yeast. Cid VCJ, et al. Microbiology (Reading), 2001 Jun. PMID 11390675

    See all (175) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-4-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-5-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in septin ring assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in ascospore-type prospore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    located_in meiotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in prospore membrane HDA PubMed 
    located_in prospore membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of septin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of septin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in septin filament array IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    septin CDC10
    NP_009928.1
    • Component of the septin ring, required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus interacts with phosphatidylinositol-4,5-bisphosphate; protein abundance increases under DNA damage stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      117380..118348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178715.1 → NP_009928.1  TPA: septin CDC10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009928.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR12, P25342
      UniProtKB/TrEMBL
      A6ZTI4, B3LU74, B5VEV0, C7GQL5, C8Z487, G2WA20, N1P684
      Conserved Domains (1) summary
      COG5019
      Location:11 → 322
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25342.1

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