Ifi208 interferon activated gene 208 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifi208provided by MGI
Official Full Name: interferon activated gene 208provided by MGI
Primary source: MGI:MGI:2442822
See related: Ensembl:ENSMUSG00000066677 AllianceGenome:MGI:2442822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pydc3; Pyr-rv1; NG2creBAC; 9830148g24rik; E430029J22Rik; Tg(Cspg4-cre)1Akik
Summary: Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Predicted to be involved in several processes, including regulation of cysteine-type endopeptidase activity; regulation of gene expression; and regulation of innate immune response. Predicted to be located in nucleolus. Predicted to be active in cytosol and nucleoplasm. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 5.2), mammary gland adult (RPKM 5.0) and 8 other tissues See more
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Genomic context

Location:: 1 H3; 1 80.57 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (173501194..173525959)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (173673628..173698393)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to interferon-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in monocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of AIM2 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-activable protein 208

Names: inteferon-activable protein 208; pyrin domain containing 3; pyrin domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162938.2 → NP_001156410.1 interferon-activable protein 208 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC117682

Consensus CDS

CCDS48451.1

UniProtKB/Swiss-Prot

Q3V3Q4, Q8BLW5

Related

ENSMUSP00000083039.4, ENSMUST00000085876.12

Conserved Domains (2) summary

cd08305
Location:14 → 84

Pyrin; Pyrin: a protein-protein interaction domain

pfam15695
Location:505 → 570

HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113
NM_001379481.1 → NP_001366410.1 interferon-activable protein 208 isoform 2

Status: VALIDATED

Source sequence(s)

AC117682

Conserved Domains (1) summary

cd08305
Location:14 → 84

Pyrin; a protein-protein interaction domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

173501194..173525959

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011238729.3 → XP_011237031.1 interferon-activable protein 208 isoform X1

Conserved Domains (4) summary

PRK06347
Location:88 → 228

PRK06347; 1,4-beta-N-acetylmuramoylhydrolase

cd08305
Location:14 → 84

Pyrin; a protein-protein interaction domain

TIGR00601
Location:176 → 345

rad23; UV excision repair protein Rad23

pfam15695
Location:505 → 572

HERV-K_REC; Rec (regulator of expression encoded by corf) of HERV-K-113