Ifi205 interferon activated gene 205 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifi205provided by MGI
Official Full Name: interferon activated gene 205provided by MGI
Primary source: MGI:MGI:101847
See related: Ensembl:ENSMUSG00000054203 AllianceGenome:MGI:101847
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D3; D3cDNA; Ifi205a
Summary: Enables double-stranded DNA binding activity. Acts upstream of or within cellular response to interferon-beta and response to bacterium. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytosol; nucleolus; and nucleoplasm. Is expressed in several structures, including adrenal gland; cerebral cortex; hemolymphoid system; sensory organ; and skeleton. Orthologous to several human genes including IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in mammary gland adult (RPKM 5.0), bladder adult (RPKM 4.0) and 15 other tissues See more
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Genomic context

Location:: 1 H3; 1 80.83 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (173839549..173859617, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (174011998..174031755, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings show that the mouse ALR IFI205 senses self DNA derived from retrotransposons in the cytoplasm of macrophages and activates the type I IFN signaling pathway via STING; suggest that ALRs, including IFI205 and AIM2, function together with cGAS as positive and negative regulators of the innate immune response to cytosolic self DNAs
Title: AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA.
This study aimed to determine whether p205 is involved in adipogenesis of mouse adipose-derived stem cells.
Title: Interferon-inducible protein 205 (p205) plays a role in adipogenic differentiation of mouse adipose-derived stem cells.
p205 induces growth arrest by interaction with multiple transcription factors that regulate the cell cycle, including but not entirely dependent on the Rb- and p53-mediated pathways of growth inhibition
Title: p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Mnda (e-PCR), detects polymorphism
- UniSTS:547266

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interferon-beta	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-activable protein 205-A

Names: ifi-205-A; interferon-inducible protein p205-A; protein D3'

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172648.3 → NP_766236.2 interferon-activable protein 205-A

See identical proteins and their annotated locations for NP_766236.2

Status: PROVISIONAL

Source sequence(s)

AC118013

Consensus CDS

CCDS15534.1

UniProtKB/Swiss-Prot

Q8BYE7, Q8CGE8

UniProtKB/TrEMBL

A0A1Z3MI21

Related

ENSMUSP00000062409.7, ENSMUST00000059226.7

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:204 → 372

HIN; HIN-200/IF120x domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

173839549..173859617 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164161.1 → XP_036020054.1 interferon-activable protein 205-A isoform X1

UniProtKB/TrEMBL

A0A1Z3MI21

Conserved Domains (2) summary

cd08305
Location:10 → 83

Pyrin; a protein-protein interaction domain

pfam02760
Location:202 → 370

HIN; HIN-200/IF120x domain