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    Rdh19 retinol dehydrogenase 19 [ Mus musculus (house mouse) ]

    Gene ID: 216453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rdh19provided by MGI
    Official Full Name
    retinol dehydrogenase 19provided by MGI
    Primary source
    MGI:MGI:2678390
    See related
    Ensembl:ENSMUSG00000054052 AllianceGenome:MGI:2678390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rdhs; RDH-S; RDH-S2
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity; androstan-3-alpha,17-beta-diol dehydrogenase activity; and androsterone dehydrogenase activity. Predicted to be involved in positive regulation of retinoic acid biosynthetic process; retinoid metabolic process; and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver and metanephros. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 16.1), kidney adult (RPKM 5.1) and 4 other tissues See more
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    Genomic context

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    See Rdh19 in Genome Data Viewer
    Location:
    10 D3; 10 76.27 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127685797..127697045)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127849928..127861176)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 16 Neighboring gene STARR-seq mESC enhancer starr_28238 Neighboring gene STARR-seq mESC enhancer starr_28239 Neighboring gene retinol dehydrogenase 18, pseudogene Neighboring gene STARR-seq mESC enhancer starr_28240 Neighboring gene RDH16 family member 2 Neighboring gene predicted gene, 31091 Neighboring gene retinol dehydrogenase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a mouse short-chain dehydrogenase/reductase gene, retinol dehydrogenase-similar. Function of non-catalytic amino acid residues in enzyme activity. Song MS, et al. J Biol Chem, 2003 Oct 10. PMID 12855677
    2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables all-trans-retinol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of retinoic acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinoic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase similar protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_147222.2 → NP_671755.2  retinol dehydrogenase similar protein 2 precursor

      See identical proteins and their annotated locations for NP_671755.2

      Status: VALIDATED

      Source sequence(s)
      AC131690
      Consensus CDS
      CCDS24253.1
      UniProtKB/TrEMBL
      G5E8H9, Q8K3M9
      Related
      ENSMUSP00000076735.3, ENSMUST00000077530.3
      Conserved Domains (2) summary
      cd09805
      Location:30 → 306
      type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
      pfam00106
      Location:30 → 219
      adh_short; short chain dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127685797..127697045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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