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    Leo1 Leo1, Paf1/RNA polymerase II complex component [ Mus musculus (house mouse) ]

    Gene ID: 235497, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Leo1provided by MGI
    Official Full Name
    Leo1, Paf1/RNA polymerase II complex componentprovided by MGI
    Primary source
    MGI:MGI:2685031
    See related
    Ensembl:ENSMUSG00000042487 AllianceGenome:MGI:2685031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm185
    Summary
    Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in endodermal cell fate commitment and stem cell population maintenance. Predicted to be located in centrosome; fibrillar center; and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. Is expressed in brain; gonad; heart; and medial-nasal process mesenchyme. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.3), CNS E14 (RPKM 6.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Leo1 in Genome Data Viewer
    Location:
    9 D; 9 42.3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75348072..75373714)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75441015..75466432)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:75249977-75250086 Neighboring gene mitogen-activated protein kinase 6 Neighboring gene STARR-positive B cell enhancer ABC_E11414 Neighboring gene RIKEN cDNA 4933433G15 gene Neighboring gene STARR-positive B cell enhancer ABC_E3844 Neighboring gene STARR-positive B cell enhancer ABC_E6767 Neighboring gene STARR-seq mESC enhancer starr_24669 Neighboring gene predicted gene, 57538 Neighboring gene predicted gene 7972 Neighboring gene tropomodulin 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75407347-75407647

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Protein Degradation of RNA Polymerase II-Association Factor 1(PAF1) Is Controlled by CNOT4 and 26S Proteasome. Sun HY, et al. PLoS One, 2015. PMID 25933433, Free PMC Article
    2. The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. Zhang C, et al. Neuron, 2013 Jun 19. PMID 23791194, Free PMC Article
    3. Finding the Unicorn, a New Mouse Model of Midfacial Clefting. Lantz B, et al. Genes (Basel), 2020 Jan 11. PMID 31940751, Free PMC Article
    4. Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation. Vethantham V, et al. Mol Cell Biol, 2012 Mar. PMID 22252316, Free PMC Article
    5. Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Strikoudis A, et al. Nat Cell Biol, 2016 Nov. PMID 27749823, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC100232, MGC102277

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA polymerase II C-terminal domain phosphoserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endodermal cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription elongation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Cdc73/Paf1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cdc73/Paf1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA polymerase-associated protein LEO1
    Names
    Leo1, Paf1/RNA polymerase II complex component, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039522.1 → NP_001034611.1  RNA polymerase-associated protein LEO1

      See identical proteins and their annotated locations for NP_001034611.1

      Status: VALIDATED

      Source sequence(s)
      BC082540, BC083358, CB248994
      Consensus CDS
      CCDS23343.1
      UniProtKB/Swiss-Prot
      E9QPK8, Q5XJE5, Q640R1
      Related
      ENSMUSP00000046905.5, ENSMUST00000048937.6
      Conserved Domains (2) summary
      PHA02664
      Location:61 → 209
      PHA02664; hypothetical protein; Provisional
      pfam04004
      Location:375 → 533
      Leo1; Leo1-like protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      75348072..75373714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313344.3 → XP_017168833.1  RNA polymerase-associated protein LEO1 isoform X1

      Conserved Domains (2) summary
      COG5271
      Location:43 → 351
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      pfam04004
      Location:375 → 537
      Leo1; Leo1-like protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001006122.1: Suppressed sequence

      Description
      NM_001006122.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XJE5.2 GenPept UniProtKB/Swiss-Prot:Q5XJE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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