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    Gadd45g growth arrest and DNA-damage-inducible 45 gamma [ Mus musculus (house mouse) ]

    Gene ID: 23882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gadd45gprovided by MGI
    Official Full Name
    growth arrest and DNA-damage-inducible 45 gammaprovided by MGI
    Primary source
    MGI:MGI:1346325
    See related
    Ensembl:ENSMUSG00000021453 AllianceGenome:MGI:1346325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CR6; DDIT2; OIG37
    Summary
    Enables identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within negative regulation of protein kinase activity; positive regulation of MAPK cascade; and regulation of cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human GADD45G (growth arrest and DNA damage inducible gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 76.7), CNS E14 (RPKM 36.6) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gadd45g in Genome Data Viewer
    Location:
    13 A5; 13 26.36 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (52000711..52002511)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (51846675..51848475)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Neighboring gene STARR-seq mESC enhancer starr_34521 Neighboring gene STARR-positive B cell enhancer ABC_E11544 Neighboring gene STARR-positive B cell enhancer ABC_E4068 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51862969-51863152 Neighboring gene predicted gene, 19281 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51896377-51896617 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51909396-51909586 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:51941838-51941947 Neighboring gene VISTA enhancer mm1565 Neighboring gene STARR-seq mESC enhancer starr_34529 Neighboring gene STARR-seq mESC enhancer starr_34531 Neighboring gene STARR-seq mESC enhancer starr_34532 Neighboring gene predicted gene, 26651 Neighboring gene STARR-seq mESC enhancer starr_34533 Neighboring gene predicted gene, 40948

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Lu B, et al. Immunity, 2001 May. PMID 11371360
    2. Gadd45γ regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling. Lucas A, et al. Cardiovasc Res, 2015 Nov 1. PMID 26370247
    3. The DNA Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of Immediate Early Gene Expression within the Prelimbic Prefrontal Cortex and Is Required for the Consolidation of Associative Fear Memory. Li X, et al. J Neurosci, 2019 Feb 6. PMID 30545945, Free PMC Article
    4. Mimicking Age-Associated Gadd45γ Dysregulation Results in Memory Impairments in Young Adult Mice. Brito DVC, et al. J Neurosci, 2020 Feb 5. PMID 31826946, Free PMC Article
    5. Gadd45gamma is dispensable for normal mouse development and T-cell proliferation. Hoffmeyer A, et al. Mol Cell Biol, 2001 May. PMID 11287618, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.
      Title: Gadd45g insufficiency drives the pathogenesis of myeloproliferative neoplasms.
    2. Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation.
      Title: Gadd45g, A Novel Antidepressant Target, Mediates Metformin-Induced Neuronal Differentiation of Neural Stem Cells Via DNA Demethylation.
    3. MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
      Title: MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
    4. Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
      Title: Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g.
    5. Mimicking Age-Associated Gadd45gamma Dysregulation Results in Memory Impairments in Young Adult Mice.
      Title: Mimicking Age-Associated Gadd45γ Dysregulation Results in Memory Impairments in Young Adult Mice.
    6. during fear learning, Gadd45gamma serves to act as a coordinator of immediate early gene expression and subsequent memory consolidation by directing temporally specific changes in active DNA demethylation at the promoter of plasticity-related immediate early genes
      Title: The DNA Repair-Associated Protein Gadd45γ Regulates the Temporal Coding of Immediate Early Gene Expression within the Prelimbic Prefrontal Cortex and Is Required for the Consolidation of Associative Fear Memory.
    7. PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin pathway and up-regulating GADD45G expression.
      Title: Paired box 5 is a frequently methylated lung cancer tumour suppressor gene interfering β-catenin signalling and GADD45G expression.
    8. accumulation during myocardial infarction promotes the development and persistence of heart failure by inducing cardiomyocyte apoptosis in a p38 MAPK-dependent manner
      Title: Gadd45γ regulates cardiomyocyte death and post-myocardial infarction left ventricular remodelling.
    9. Results suggest the possibility that differential Gadd45a, Gadd45b and Gadd45g expression during development affects neurons, contributing cortical evolution and diversity
      Title: Comparative analysis of developmentally regulated expressions of Gadd45a, Gadd45b, and Gadd45g in the mouse and marmoset cerebral cortex.
    10. The Gadd45g-d4Venus mice exhibited very similar labeling patterns in the ventricular zone (VZ), in Gadd45g-d4Venus mice cells could be visualized in more basal areas containing fully differentiated neurons.
      Title: Neurogenin2-d4Venus and Gadd45g-d4Venus transgenic mice: visualizing mitotic and migratory behaviors of cells committed to the neuronal lineage in the developing mammalian brain.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T-helper 1 cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within type II interferon production TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    growth arrest and DNA damage-inducible protein GADD45 gamma
    Names
    cytokine-responsive protein CR6
    growth arrest and DNA-damage-inducible, gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011817.2 → NP_035947.2  growth arrest and DNA damage-inducible protein GADD45 gamma

      See identical proteins and their annotated locations for NP_035947.2

      Status: VALIDATED

      Source sequence(s)
      AC126247
      Consensus CDS
      CCDS26515.1
      UniProtKB/TrEMBL
      Q99M58, Q9R0S0
      Related
      ENSMUSP00000021903.3, ENSMUST00000021903.3
      Conserved Domains (1) summary
      pfam01248
      Location:24 → 106
      Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      52000711..52002511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z111.1 GenPept UniProtKB/Swiss-Prot:Q9Z111

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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