Rae1 ribonucleic acid export 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rae1provided by MGI
Official Full Name: ribonucleic acid export 1provided by MGI
Primary source: MGI:MGI:1913929
See related: Ensembl:ENSMUSG00000027509 AllianceGenome:MGI:1913929
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MNRP; MNRP41; D2Ertd342e; 3230401I12Rik
Summary: Predicted to enable RNA binding activity and ubiquitin binding activity. Acts upstream of or within cellular response to organic cyclic compound. Predicted to be located in mitotic spindle pole and nucleus. Predicted to be part of nuclear pore. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular layer; and cortical plate. Orthologous to human RAE1 (ribonucleic acid export 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 61.6), ovary adult (RPKM 34.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 95.66 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (172841909..172857532)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (173000116..173015739)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition.
Title: RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition.
Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes.
Title: Ribonucleic Acid Export 1 Is a Kinetochore-Associated Protein That Participates in Chromosome Alignment in Mouse Oocytes.
RAE1 and NUP98 participate inBMAL1 shuttling and promote the degradation and activity of BMAL1 and CLOCK.
Title: RAE1 promotes BMAL1 shuttling and regulates degradation and activity of CLOCK: BMAL1 heterodimer.
surface NKG2D ligand RAE1epsilon on tumour cells induces CD11b(+) Gr-1(+) myeloid-derived suppressor cell (MDSC) via NKG2D in vitro and in vivo.
Title: NKG2D ligand RAE1ε induces generation and enhances the inhibitor function of myeloid-derived suppressor cells in mice.
The authors observed that the mouse cytomegalovirus encoded protein m18 is necessary and sufficient to drive expression of the RAE-1 family of NKG2D ligands. RAE-1 is transcriptionally repressed by histone deacetylase inhibitor 3 (HDAC3) in healthy cells, and m18 relieves this repression by directly interacting with Casein Kinase II and preventing it from activating HDAC3.
Title: A Herpesviral induction of RAE-1 NKG2D ligand expression occurs through release of HDAC mediated repression.
High RAE1 expression is associated with lymphoma.
Title: CBP/p300 acetyltransferases regulate the expression of NKG2D ligands on tumor cells.
Viral infection of cultured cells increased RAE-1 expression, resulting in enhanced NK cell-mediated killing through NKG2D recognition.
Title: Activating receptor NKG2D targets RAE-1-expressing allogeneic neural precursor cells in a viral model of multiple sclerosis.
An increased expression of the NKG2D ligand MICA in systemic lupus erthematosus (SLE) patients' kidneys and Rae-1 and Mult-1 in various murine SLE models, is reported.
Title: NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.
Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-gamma in experimental dry eye.
Title: Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-γ in experimental dry eye.
Highly target-specific liver NKT cells selectively remove activated hepatic stellate cells through an NKG2D-Rae1 interaction to ameliorate liver fibrosis after IL-30 treatment.
Title: IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI327368 (e-PCR)
- UniSTS:207450

RH127002 (e-PCR)
- UniSTS:167313

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleocytoplasmic transport	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic spindle organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mRNA export factor

Names: RAE1 RNA export 1 homolog; mRNA-associated protein mrnp 41; rae1 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175112.5 → NP_780321.1 mRNA export factor

See identical proteins and their annotated locations for NP_780321.1

Status: VALIDATED

Source sequence(s)

AL928599, BC059051, CO041965

Consensus CDS

CCDS17138.1

UniProtKB/Swiss-Prot

Q3UKD4, Q8C570

UniProtKB/TrEMBL

Q8CBU3

Related

ENSMUSP00000029013.4, ENSMUST00000029013.10

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

172841909..172857532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500024.5 → XP_006500087.1 mRNA export factor isoform X1

See identical proteins and their annotated locations for XP_006500087.1

UniProtKB/Swiss-Prot

Q3UKD4, Q8C570

UniProtKB/TrEMBL

Q8CBU3

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006500023.2 → XP_006500086.1 mRNA export factor isoform X1

See identical proteins and their annotated locations for XP_006500086.1

UniProtKB/Swiss-Prot

Q3UKD4, Q8C570

UniProtKB/TrEMBL

Q8CBU3

Conserved Domains (2) summary

sd00039
Location:42 → 84

7WD40; WD40 repeat [structural motif]

cl29593
Location:40 → 335

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...