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    Wdr38 WD repeat domain 38 [ Mus musculus (house mouse) ]

    Gene ID: 76646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr38provided by MGI
    Official Full Name
    WD repeat domain 38provided by MGI
    Primary source
    MGI:MGI:1923896
    See related
    Ensembl:ENSMUSG00000035295 AllianceGenome:MGI:1923896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700123D08Rik
    Summary
    Acts upstream of or within hematopoietic progenitor cell differentiation. Orthologous to human WDR38 (WD repeat domain 38). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 33.3) and ovary adult (RPKM 2.4) See more
    Orthologs
    human all
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    Genomic context

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    See Wdr38 in Genome Data Viewer
    Location:
    2 B; 2 24.42 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38888287..38891600)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (38998309..39001584)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39801 Neighboring gene predicted gene, 29985 Neighboring gene STARR-positive B cell enhancer ABC_E5911 Neighboring gene STARR-positive B cell enhancer ABC_E4447 Neighboring gene ribosomal protein L35 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38866813-38867114 Neighboring gene actin related protein 2/3 complex, subunit 5-like Neighboring gene golgin A1 Neighboring gene predicted gene, 26127

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis. Gao Q, et al. Acta Biochim Biophys Sin (Shanghai), 2023 Oct 25. PMID 37635409, Free PMC Article
    2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    3. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
      Title: WDR38, a novel equatorial segment protein, interacts with the GTPase protein RAB19 and Golgi protein GM130 to play roles in acrosome biogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 38
    Names
    novel WD domain, G-beta repeat domain containing protein (1700123D08Rik)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029687.4 → NP_083963.1  WD repeat-containing protein 38

      See identical proteins and their annotated locations for NP_083963.1

      Status: VALIDATED

      Source sequence(s)
      AL844588
      Consensus CDS
      CCDS38119.1
      UniProtKB/Swiss-Prot
      Q9D994
      Related
      ENSMUSP00000108493.2, ENSMUST00000112872.2
      Conserved Domains (3) summary
      COG2319
      Location:18 → 300
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:25 → 300
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:31 → 66
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      38888287..38891600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162672.1 → XP_036018565.1  WD repeat-containing protein 38 isoform X1

      Conserved Domains (2) summary
      cd00200
      Location:63 → 294
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:66 → 102
      7WD40; WD40 repeat [structural motif]

    2. XM_036162673.1 → XP_036018566.1  WD repeat-containing protein 38 isoform X2

      Conserved Domains (2) summary
      cd00200
      Location:25 → 279
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:31 → 66
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_004940766.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D994.1 GenPept UniProtKB/Swiss-Prot:Q9D994

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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