Npepl1 aminopeptidase-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Npepl1provided by MGI
Official Full Name: aminopeptidase-like 1provided by MGI
Primary source: MGI:MGI:2448523
See related: Ensembl:ENSMUSG00000039263 AllianceGenome:MGI:2448523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1974
Summary: Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human NPEPL1 (aminopeptidase like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 80.4), adrenal adult (RPKM 69.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 97.87 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (173951904..173964495)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (174110338..174122702)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

C85514 (e-PCR)
- UniSTS:159083

RH129102 (e-PCR)
- UniSTS:212410

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: probable aminopeptidase NPEPL1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378793.1 → NP_001365722.1 probable aminopeptidase NPEPL1 isoform 1

Status: VALIDATED

Source sequence(s)

AL669896

UniProtKB/TrEMBL

Q3TCV9, Q3U199, Q3UD03

Conserved Domains (1) summary

cd00433
Location:35 → 492

Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...
NM_213733.2 → NP_998898.1 probable aminopeptidase NPEPL1 isoform 2

See identical proteins and their annotated locations for NP_998898.1

Status: VALIDATED

Source sequence(s)

AK150313, BU148687, BX517579

Consensus CDS

CCDS17148.1

UniProtKB/Swiss-Prot

A2ACM6, Q66JY0, Q6NSR8

UniProtKB/TrEMBL

Q3TCV9, Q3U199, Q3UD03

Related

ENSMUSP00000042808.10, ENSMUST00000044415.16

Conserved Domains (1) summary

cd00433
Location:35 → 487

Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...