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    Sspo SCO-spondin [ Mus musculus (house mouse) ]

    Gene ID: 243369, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sspoprovided by MGI
    Official Full Name
    SCO-spondinprovided by MGI
    Primary source
    MGI:MGI:2674311
    See related
    Ensembl:ENSMUSG00000029797 AllianceGenome:MGI:2674311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scospondin
    Summary
    Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Located in cytoplasm. Is expressed in several structures, including central nervous system. Orthologous to human SSPOP (SCO-spondin, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 4.1), colon adult (RPKM 1.4) and 14 other tissues See more
    Orthologs
    all
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    Genomic context

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    See Sspo in Genome Data Viewer
    Location:
    6 B2.3; 6 23.42 cM
    Exon count:
    106
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48423164..48478196)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48446230..48501262)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38803 Neighboring gene predicted gene, 57777 Neighboring gene zinc finger protein 467 Neighboring gene STARR-positive B cell enhancer mm9_chr6:48394046-48394347 Neighboring gene zinc finger protein 862, pseudogene Neighboring gene ribosomal protein L35a pseudogene Neighboring gene PEST proteolytic signal containing nuclear protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation. Xu H, et al. Fluids Barriers CNS, 2023 Dec 5. PMID 38049798, Free PMC Article
    2. Placental expression of SCO-spondin during mouse and human development. Gonçalves-Mendes N, et al. Gene Expr Patterns, 2004 May. PMID 15053980
    3. Mouse SCO-spondin, a gene of the thrombospondin type 1 repeat (TSR) superfamily expressed in the brain. Gonçalves-Mendes N, et al. Gene, 2003 Jul 17. PMID 12909363
    4. The complex multidomain organization of SCO-spondin protein is highly conserved in mammals. Meiniel O, et al. Brain Res Rev, 2007 Feb. PMID 17126404
    5. The lengthening of a giant protein: when, how, and why? Meiniel O, et al. J Mol Evol, 2008 Jan. PMID 18046595

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation.
      Title: SCO-spondin knockout mice exhibit small brain ventricles and mild spine deformation.
    2. demonstrated SCO-spondin expression at relevant steps of gestation in the placenta
      Title: Placental expression of SCO-spondin during mouse and human development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SCO-spondin
    Names
    subcommissural organ spondin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173428.4 → NP_775604.3  SCO-spondin precursor

      Status: VALIDATED

      Source sequence(s)
      AC153815
      Consensus CDS
      CCDS57420.1
      UniProtKB/TrEMBL
      A0A1D5RLZ9, E9Q0I4
      Related
      ENSMUSP00000131401.3, ENSMUST00000169350.9
      Conserved Domains (14) summary
      smart00192
      Location:1495 → 1526
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2539 → 2591
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2928 → 2975
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:556 → 716
      VWD; von Willebrand factor (vWF) type D domain
      smart00231
      Location:2070 → 2225
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      smart00832
      Location:754 → 826
      C8; This domain contains 8 conserved cysteine residues
      cd00057
      Location:2105 → 2225
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cd00112
      Location:1419 → 1453
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00057
      Location:1566 → 1602
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2815 → 2863
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1017 → 1166
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:472 → 527
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1204 → 1274
      C8; C8 domain
      cl17735
      Location:4980 → 5035
      VWC; von Willebrand factor type C domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      48423164..48478196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506069.4 → XP_006506132.1  SCO-spondin isoform X5

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1495 → 1526
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2528 → 2580
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2917 → 2964
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:556 → 716
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:754 → 826
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1419 → 1453
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:4971 → 5026
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2105 → 2225
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1566 → 1602
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2804 → 2852
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1017 → 1164
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:472 → 527
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1208 → 1274
      C8; C8 domain

    2. XM_017321577.1 → XP_017177066.1  SCO-spondin isoform X5

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1495 → 1526
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2528 → 2580
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2917 → 2964
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:556 → 716
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:754 → 826
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1419 → 1453
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:4971 → 5026
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2105 → 2225
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1566 → 1602
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2804 → 2852
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1017 → 1164
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:472 → 527
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1208 → 1274
      C8; C8 domain

    3. XM_036166109.1 → XP_036022002.1  SCO-spondin isoform X16

      Conserved Domains (14) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:2007 → 2063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00094
      Location:1054 → 1203
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1244 → 1311
      C8; C8 domain
      pfam19028
      Location:2508 → 2559
      TSP1_spondin; Spondin-like TSP1 domain
      cd19941
      Location:866 → 919
      TIL; trypsin inhibitor-like cysteine rich domain

    4. XM_017321581.2 → XP_017177070.1  SCO-spondin isoform X14

      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:2007 → 2063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam03154
      Location:2313 → 2423
      Atrophin-1; Atrophin-1 family
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    5. XM_017321582.2 → XP_017177071.1  SCO-spondin isoform X15

      Conserved Domains (14) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:2007 → 2063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam03154
      Location:2313 → 2423
      Atrophin-1; Atrophin-1 family
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    6. XM_036166108.1 → XP_036022001.1  SCO-spondin isoform X11

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (15) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:4882 → 4937
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1203
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1244 → 1311
      C8; C8 domain
      pfam19028
      Location:3412 → 3458
      TSP1_spondin; Spondin-like TSP1 domain
      cd19941
      Location:866 → 919
      TIL; trypsin inhibitor-like cysteine rich domain

    7. XM_017321574.3 → XP_017177063.1  SCO-spondin isoform X1

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:5008 → 5063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    8. XM_006506068.5 → XP_006506131.1  SCO-spondin isoform X3

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Related
      ENSMUSP00000148570.2, ENSMUST00000212740.2
      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:5008 → 5063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    9. XM_017321580.3 → XP_017177069.1  SCO-spondin isoform X9

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:5008 → 5063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    10. XM_017321575.3 → XP_017177064.1  SCO-spondin isoform X2

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:5008 → 5063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    11. XM_030255369.2 → XP_030111229.1  SCO-spondin isoform X10

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:5008 → 5063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    12. XM_017321578.2 → XP_017177067.1  SCO-spondin isoform X6

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:4969 → 5024
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    13. XM_030255368.2 → XP_030111228.1  SCO-spondin isoform X7

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:4969 → 5024
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    14. XM_017321579.3 → XP_017177068.1  SCO-spondin isoform X8

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (14) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2517 → 2569
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2906 → 2953
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:4960 → 5015
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2793 → 2841
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam03154
      Location:2313 → 2424
      Atrophin-1; Atrophin-1 family
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    15. XM_017321576.2 → XP_017177065.1  SCO-spondin isoform X4

      UniProtKB/TrEMBL
      A0A1D5RLZ9
      Conserved Domains (13) summary
      smart00192
      Location:1532 → 1563
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:2565 → 2617
      TSP1; Thrombospondin type 1 repeats
      smart00215
      Location:2954 → 3001
      VWC_out; von Willebrand factor (vWF) type C domain
      smart00216
      Location:593 → 753
      VWD; von Willebrand factor (vWF) type D domain
      smart00832
      Location:791 → 863
      C8; This domain contains 8 conserved cysteine residues
      cd00112
      Location:1456 → 1490
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:5008 → 5063
      VWC; von Willebrand factor type C domain
      cl25480
      Location:2142 → 2262
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:1603 → 1639
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:2841 → 2889
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:1054 → 1201
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:509 → 564
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:1245 → 1311
      C8; C8 domain

    16. XM_006506070.3 → XP_006506133.1  SCO-spondin isoform X12

      UniProtKB/Swiss-Prot
      E9QMN0, Q8CG65
      Conserved Domains (10) summary
      smart00192
      Location:667 → 698
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:1700 → 1752
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:591 → 625
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:2089 → 2136
      VWC; von Willebrand factor type C domain
      cl25480
      Location:1277 → 1397
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:738 → 774
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:1976 → 2024
      TSP_1; Thrombospondin type 1 domain
      pfam00094
      Location:189 → 336
      VWD; von Willebrand factor type D domain
      pfam01826
      Location:450 → 506
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:380 → 446
      C8; C8 domain

    17. XM_006506071.1 → XP_006506134.1  SCO-spondin isoform X13

      UniProtKB/Swiss-Prot
      E9QMN0, Q8CG65
      Conserved Domains (10) summary
      smart00192
      Location:470 → 501
      LDLa; Low-density lipoprotein receptor domain class A
      smart00209
      Location:1503 → 1555
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:394 → 428
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cl17735
      Location:1892 → 1939
      VWC; von Willebrand factor type C domain
      cl25480
      Location:1080 → 1200
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam00057
      Location:541 → 577
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00090
      Location:1779 → 1827
      TSP_1; Thrombospondin type 1 domain
      pfam01826
      Location:253 → 309
      TIL; Trypsin Inhibitor like cysteine rich domain
      pfam08742
      Location:183 → 249
      C8; C8 domain
      cl02516
      Location:60 → 139
      VWD; von Willebrand factor type D domain

    RNA

    1. XR_001785128.3 RNA Sequence

    2. XR_003956195.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CG65.2 GenPept UniProtKB/Swiss-Prot:Q8CG65

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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