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    HXT16 hexose transporter HXT16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853623, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HXT16
    Official Full Name
    hexose transporter HXT16
    Primary source
    SGD:S000003919
    Locus tag
    YJR158W
    See related
    AllianceGenome:SGD:S000003919; FungiDB:YJR158W; VEuPathDB:YJR158W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HLT3
    Summary
    Enables D-glucose transmembrane transporter activity; fructose transmembrane transporter activity; and mannose transmembrane transporter activity. Involved in hexose transmembrane transport; mannitol transmembrane transport; and sorbitol transmembrane transport. Located in cell periphery. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HXT16 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (732440..734143)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene putative aryl-alcohol dehydrogenase Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene L-iditol 2-dehydrogenase SOR1 Neighboring gene alpha-glucoside permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription of hexose transporters of Saccharomyces cerevisiae is affected by change in oxygen provision. Rintala E, et al. BMC Microbiol, 2008 Mar 28. PMID 18373847, Free PMC Article
    2. Hxt13, Hxt15, Hxt16 and Hxt17 from Saccharomyces cerevisiae represent a novel type of polyol transporters. Jordan P, et al. Sci Rep, 2016 Mar 21. PMID 26996892, Free PMC Article
    3. Uptake of radiolabeled GlcNAc into Saccharomyces cerevisiae via native hexose transporters and its in vivo incorporation into GPI precursors in cells expressing heterologous GlcNAc kinase. Scarcelli JJ, et al. FEMS Yeast Res, 2012 May. PMID 22151002, Free PMC Article
    4. Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. Wieczorke R, et al. FEBS Lett, 1999 Dec 31. PMID 10618490
    5. The yeast Ty1 retrotransposon requires components of the nuclear pore complex for transcription and genomic integration. Manhas S, et al. Nucleic Acids Res, 2018 Apr 20. PMID 29514267, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables carbohydrate:proton symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mannose transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mannitol transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mannose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sorbitol transmembrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hexose transporter HXT16
    NP_012692.3
    • Putative transmembrane polyol transporter; supports growth on and uptake of sorbitol with moderate affinity and mannitol with lower affinity when overexpressed in a strain deleted for hexose family members; minor hexose transport activity when overexpressed in a similar strain; similarity to hexose transporters; expression is repressed by high levels of glucose

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      732440..734143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181816.3 → NP_012692.3  TPA: hexose transporter HXT16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012692.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWX6, P47185
      UniProtKB/TrEMBL
      A6ZX90
      Conserved Domains (2) summary
      cd06174
      Location:67 → 510
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:63 → 524
      Sugar_tr; Sugar (and other) transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47185.1

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