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    Ddx3x DEAD box helicase 3, X-linked [ Mus musculus (house mouse) ]

    Gene ID: 13205, updated on 13-Jan-2025

    Summary

    Official Symbol
    Ddx3xprovided by MGI
    Official Full Name
    DEAD box helicase 3, X-linkedprovided by MGI
    Primary source
    MGI:MGI:103064
    See related
    Ensembl:ENSMUSG00000000787 AllianceGenome:MGI:103064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ddx3; Fin14; D1Pas1-rs2
    Summary
    Enables primary miRNA binding activity. Involved in positive regulation of NLRP3 inflammasome complex assembly and stress granule assembly. Acts upstream of or within with a negative effect on primary miRNA processing. Located in cytoplasmic stress granule. Part of NLRP3 inflammasome complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in CNS E11.5 (RPKM 64.5), placenta adult (RPKM 53.4) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Ddx3x in Genome Data Viewer
    Location:
    X A1.1; X 8.17 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (13147261..13160222)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (13280496..13293988)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene LLP homolog, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chrX:12807869-12808169 Neighboring gene RIKEN cDNA 2010308F09 gene Neighboring gene VISTA enhancer mm1613 Neighboring gene ATP-binding cassette, sub-family F (GCN20), member 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_46787 Neighboring gene STARR-seq mESC enhancer starr_46788 Neighboring gene chaperonin containing Tcp1, subunit 7 (eta) pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 45
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables CTPase activity  
    enables DNA binding  
    enables DNA binding  
    enables DNA clamp loader activity  
    enables DNA helicase activity  
    enables DNA helicase activity  
    enables GTPase activity  
    enables RNA binding  
    enables RNA binding  
    enables RNA helicase activity  
    enables RNA helicase activity  
    enables RNA helicase activity  
    enables RNA stem-loop binding  
    enables RNA stem-loop binding  
    enables RNA strand annealing activity  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables eukaryotic initiation factor 4E binding  
    enables eukaryotic initiation factor 4E binding  
    enables gamma-tubulin binding  
    enables gamma-tubulin binding  
    enables mRNA 5'-UTR binding  
    enables mRNA 5'-UTR binding  
    enables mRNA binding  
    enables mRNA binding  
    enables mRNA binding  
    enables poly(A) binding  
    enables poly(A) binding  
    enables primary miRNA binding PubMed 
    enables protein binding PubMed 
    enables protein serine/threonine kinase activator activity  
    enables protein serine/threonine kinase activator activity  
    enables ribonucleoside triphosphate phosphatase activity  
    enables ribosomal small subunit binding  
    enables ribosomal small subunit binding  
    enables signaling adaptor activity  
    enables transcription factor binding  
    enables transcription factor binding  
    enables translation initiation factor binding  
    enables translation initiation factor binding  
    Items 1 - 25 of 45
    Items 1 - 25 of 93
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding  
    involved_in RNA secondary structure unwinding  
    involved_in RNA secondary structure unwinding  
    involved_in Wnt signaling pathway  
    involved_in cell differentiation  
    involved_in cellular response to arsenic-containing substance  
    involved_in cellular response to arsenic-containing substance  
    involved_in cellular response to osmotic stress  
    involved_in cellular response to osmotic stress  
    involved_in cellular response to virus  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in chromosome segregation  
    involved_in chromosome segregation  
    involved_in cytosolic ribosome assembly  
    involved_in cytosolic ribosome assembly  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in gamete generation  
    involved_in inflammatory response  
    involved_in innate immune response  
    involved_in innate immune response  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction  
    involved_in intrinsic apoptotic signaling pathway  
    involved_in intrinsic apoptotic signaling pathway  
    involved_in lipid homeostasis  
    involved_in lipid homeostasis  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cysteine-type endopeptidase activity  
    involved_in negative regulation of cysteine-type endopeptidase activity  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of intrinsic apoptotic signaling pathway  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in negative regulation of protein-containing complex assembly  
    involved_in negative regulation of protein-containing complex assembly  
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of G1/S transition of mitotic cell cycle  
    involved_in positive regulation of NLRP3 inflammasome complex assembly PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of cysteine-type endopeptidase activity  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of interferon-beta production  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of protein K63-linked ubiquitination  
    involved_in positive regulation of protein K63-linked ubiquitination  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of protein acetylation  
    involved_in positive regulation of protein autophosphorylation  
    involved_in positive regulation of protein autophosphorylation  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of protein serine/threonine kinase activity  
    involved_in positive regulation of toll-like receptor 7 signaling pathway  
    involved_in positive regulation of toll-like receptor 7 signaling pathway  
    involved_in positive regulation of toll-like receptor 8 signaling pathway  
    involved_in positive regulation of toll-like receptor 8 signaling pathway  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of translation  
    involved_in positive regulation of translation  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress  
    involved_in positive regulation of translation in response to endoplasmic reticulum stress  
    involved_in positive regulation of translational initiation  
    involved_in positive regulation of translational initiation  
    involved_in positive regulation of type I interferon production  
    involved_in positive regulation of viral genome replication  
    acts_upstream_of_or_within_negative_effect primary miRNA processing PubMed 
    acts_upstream_of_or_within_negative_effect primary miRNA processing PubMed 
    involved_in protein localization to cytoplasmic stress granule  
    involved_in response to virus  
    involved_in response to virus  
    involved_in stress granule assembly PubMed 
    involved_in stress granule assembly  
    involved_in stress granule assembly  
    involved_in translational initiation  
    Items 1 - 25 of 93
    Items 1 - 20 of 26
    Component Evidence Code Pubs
    part_of NLRP3 inflammasome complex PubMed 
    is_active_in P granule  
    located_in cell leading edge  
    located_in cell leading edge  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic stress granule PubMed 
    located_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule  
    located_in cytosol  
    part_of cytosolic small ribosomal subunit  
    part_of cytosolic small ribosomal subunit  
    part_of eukaryotic translation initiation factor 3 complex  
    part_of eukaryotic translation initiation factor 3 complex  
    located_in glutamatergic synapse  
    located_in lamellipodium  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in postsynaptic density  
    Items 1 - 20 of 26

    General protein information

    Preferred Names
    ATP-dependent RNA helicase DDX3X
    Names
    D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3
    D1Pas1-related sequence 2
    DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3
    DEAD box RNA helicase DEAD3
    DEAD box protein 3, X-chromosomal
    DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2)
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked
    embryonic RNA helicase
    fibroblast growth factor inducible 14
    mDEAD3
    NP_034158.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010028.3NP_034158.1  ATP-dependent RNA helicase DDX3X

      See identical proteins and their annotated locations for NP_034158.1

      Status: VALIDATED

      Source sequence(s)
      AK163250, AL833805, BB854842
      Consensus CDS
      CCDS30027.1
      UniProtKB/Swiss-Prot
      O09060, O09143, Q62167
      UniProtKB/TrEMBL
      B9EKE9, Q3TQX5
      Related
      ENSMUSP00000000804.7, ENSMUST00000000804.7
      Conserved Domains (4) summary
      cd00268
      Location:182404
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      PTZ00110
      Location:57580
      PTZ00110; helicase; Provisional
      pfam00271
      Location:426536
      Helicase_C; Helicase conserved C-terminal domain
      pfam06273
      Location:80172
      eIF-4B; Plant specific eukaryotic initiation factor 4B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      13147261..13160222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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