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    Adgrg5 adhesion G protein-coupled receptor G5 [ Mus musculus (house mouse) ]

    Gene ID: 382045, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Adgrg5provided by MGI
    Official Full Name
    adhesion G protein-coupled receptor G5provided by MGI
    Primary source
    MGI:MGI:2685955
    See related
    Ensembl:ENSMUSG00000061577 AllianceGenome:MGI:2685955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR27; Gm1109; Gpr114
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be active in plasma membrane. Is expressed in stomach and testis. Orthologous to human ADGRG5 (adhesion G protein-coupled receptor G5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in spleen adult (RPKM 15.2), thymus adult (RPKM 10.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adgrg5 in Genome Data Viewer
    Location:
    8 C5; 8 47.03 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95648439..95669921)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (94921811..94943293)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide C Neighboring gene docking protein 4 Neighboring gene coiled-coil domain containing 102A Neighboring gene STARR-positive B cell enhancer mm9_chr8:97441323-97441623 Neighboring gene STARR-positive B cell enhancer ABC_E8258 Neighboring gene STARR-positive B cell enhancer ABC_E3795 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97500803-97501004 Neighboring gene predicted gene, 30968 Neighboring gene adhesion G protein-coupled receptor G1 Neighboring gene predicted gene, 51544 Neighboring gene adhesion G protein-coupled receptor G3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The constitutive activity of the adhesion GPCR GPR114/ADGRG5 is mediated by its tethered agonist. Wilde C, et al. FASEB J, 2016 Feb. PMID 26499266
    2. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article
    4. The G protein-coupled receptor repertoires of human and mouse. Vassilatis DK, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12679517, Free PMC Article
    5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G-protein coupled receptor G5
    Names
    G protein coupled receptor Gpr114
    G protein-coupled receptor 114
    G-protein coupled receptor PGR27
    probable G-protein coupled receptor 114

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033468.3 → NP_001028640.2  adhesion G-protein coupled receptor G5 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has two alternate splice sites in the 5' UTR and CDS respectively, as compared to variant 1. The resulting isoform (2) lacks an internal amino acid, as compared to isoform 1.
      Source sequence(s)
      AK028878, BC144851, BY547428
      Consensus CDS
      CCDS22552.1
      UniProtKB/Swiss-Prot
      Q3V3Z3
      Related
      ENSMUSP00000074155.4, ENSMUST00000074570.10
      Conserved Domains (3) summary
      cd14964
      Location:243 → 267
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:184 → 228
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:241 → 513
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. NM_001145972.1 → NP_001139444.1  adhesion G-protein coupled receptor G5 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK028878, BC144851, BY547428
      Consensus CDS
      CCDS52637.1
      UniProtKB/Swiss-Prot
      A6H6A1, G5E8G8, Q3V3Z3
      Related
      ENSMUSP00000132628.2, ENSMUST00000166802.9
      Conserved Domains (3) summary
      cd14964
      Location:244 → 268
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:184 → 228
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:242 → 514
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      95648439..95669921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312886.1 → XP_017168375.1  adhesion G-protein coupled receptor G5 isoform X2

      UniProtKB/Swiss-Prot
      A6H6A1, G5E8G8, Q3V3Z3
      Conserved Domains (3) summary
      cd14964
      Location:244 → 268
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:184 → 228
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:242 → 514
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_017312885.1 → XP_017168374.1  adhesion G-protein coupled receptor G5 isoform X2

      UniProtKB/Swiss-Prot
      A6H6A1, G5E8G8, Q3V3Z3
      Conserved Domains (3) summary
      cd14964
      Location:244 → 268
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:184 → 228
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:242 → 514
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_011248425.1 → XP_011246727.1  adhesion G-protein coupled receptor G5 isoform X3

      Conserved Domains (3) summary
      cd14964
      Location:189 → 214
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:130 → 174
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:188 → 460
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_017312884.1 → XP_017168373.1  adhesion G-protein coupled receptor G5 isoform X2

      UniProtKB/Swiss-Prot
      A6H6A1, G5E8G8, Q3V3Z3
      Conserved Domains (3) summary
      cd14964
      Location:244 → 268
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:184 → 228
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:242 → 514
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_011248422.1 → XP_011246724.1  adhesion G-protein coupled receptor G5 isoform X1

      UniProtKB/Swiss-Prot
      Q3V3Z3
      Conserved Domains (3) summary
      cd14964
      Location:243 → 267
      7tm_GPCRs; TM helix 1 [structural motif]
      pfam01825
      Location:184 → 228
      GPS; GPCR proteolysis site, GPS, motif
      cl28897
      Location:241 → 513
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V3Z3.3 GenPept UniProtKB/Swiss-Prot:Q3V3Z3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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