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    Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) [ Mus musculus (house mouse) ]

    Gene ID: 14874, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Gstz1provided by MGI
    Official Full Name
    glutathione transferase zeta 1 (maleylacetoacetate isomerase)provided by MGI
    Primary source
    MGI:MGI:1341859
    See related
    Ensembl:ENSMUSG00000021033 AllianceGenome:MGI:1341859
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAAI; GSTZ1-1
    Summary
    Predicted to enable glutathione transferase activity; maleylacetoacetate isomerase activity; and protein homodimerization activity. Predicted to be involved in L-phenylalanine catabolic process and glutathione metabolic process. Predicted to act upstream of or within tyrosine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GSTZ1 (glutathione S-transferase zeta 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in liver adult (RPKM 145.2), subcutaneous fat pad adult (RPKM 143.0) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gstz1 in Genome Data Viewer
    Location:
    12 D2; 12 41.34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87192102..87211497)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (87147161..87164723)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 63c Neighboring gene crumbs homolog 1 pseudogene Neighboring gene neuroglobin Neighboring gene protein-O-mannosyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E10770 Neighboring gene STARR-positive B cell enhancer ABC_E10771 Neighboring gene predicted gene 6566 Neighboring gene transmembrane p24 trafficking protein 8 Neighboring gene STARR-positive B cell enhancer ABC_E9041 Neighboring gene sterile alpha motif domain containing 15 Neighboring gene NADP+ dependent oxidoreductase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Signaling metabolite succinylacetone activates HIF-1α and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma. Luo H, et al. JCI Insight, 2023 Oct 31. PMID 37906252, Free PMC Article
    2. Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Lim CE, et al. Am J Pathol, 2004 Aug. PMID 15277241, Free PMC Article
    3. Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents. Ammini CV, et al. Biochem Pharmacol, 2003 Nov 15. PMID 14599561
    4. Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism. Fernández-Cañón JM, et al. Mol Cell Biol, 2002 Jul. PMID 12052898, Free PMC Article
    5. Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Blackburn AC, et al. Mol Pharmacol, 2006 Feb. PMID 16278372

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism
      Title: Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism.
    2. GSTZ1-1 deficiency may alter the metabolism of some drugs and xenobiotics.
      Title: Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.
    3. glutathione S-transferase zeta/maleylacetoacetate isomerase is induced by C/EBPalpha and dependent on PPAR gamma
      Title: C/EBPalpha-dependent induction of glutathione S-transferase zeta/maleylacetoacetate isomerase (GSTzeta/MAAI) expression during the differentiation of mouse fibroblasts into adipocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables maleylacetoacetate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables maleylacetoacetate isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within L-phenylalanine catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tyrosine catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    maleylacetoacetate isomerase
    Names
    glutathione S-transferase zeta 1
    NP_001239484.1
    NP_001239485.1
    NP_001351235.1
    NP_001351236.1
    NP_034493.1
    XP_006515537.1
    XP_006515538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252555.1 → NP_001239484.1  maleylacetoacetate isomerase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AA244513, AB041613, AK075927
      Consensus CDS
      CCDS88379.1
      UniProtKB/TrEMBL
      A0A1Y7VNC1, Q9JJA0
      Related
      ENSMUSP00000152343.2, ENSMUST00000222885.2
      Conserved Domains (1) summary
      TIGR01262
      Location:1 → 156
      maiA; maleylacetoacetate isomerase

    2. NM_001252556.1 → NP_001239485.1  maleylacetoacetate isomerase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AA244513, AK075927, BF722376, BY072664
      Consensus CDS
      CCDS88379.1
      UniProtKB/TrEMBL
      A0A1Y7VNC1, Q9JJA0
      Related
      ENSMUSP00000152321.2, ENSMUST00000220574.2
      Conserved Domains (1) summary
      TIGR01262
      Location:1 → 156
      maiA; maleylacetoacetate isomerase

    3. NM_001364306.1 → NP_001351235.1  maleylacetoacetate isomerase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132609
      Consensus CDS
      CCDS88378.1
      UniProtKB/TrEMBL
      A0A1Y7VJZ2
      Related
      ENSMUSP00000152707.2, ENSMUST00000222222.2
      Conserved Domains (1) summary
      TIGR01262
      Location:6 → 210
      maiA; maleylacetoacetate isomerase

    4. NM_001364307.1 → NP_001351236.1  maleylacetoacetate isomerase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132609
      Consensus CDS
      CCDS88379.1
      UniProtKB/TrEMBL
      A0A1Y7VNC1, Q9JJA0
      Conserved Domains (1) summary
      TIGR01262
      Location:1 → 156
      maiA; maleylacetoacetate isomerase

    5. NM_010363.4 → NP_034493.1  maleylacetoacetate isomerase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA244513, AK075927, BY072664
      Consensus CDS
      CCDS26071.1
      UniProtKB/Swiss-Prot
      Q9WVL0
      Related
      ENSMUSP00000053540.9, ENSMUST00000063117.10
      Conserved Domains (3) summary
      cd03191
      Location:93 → 207
      GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
      cd03042
      Location:6 → 80
      GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
      TIGR01262
      Location:7 → 211
      maiA; maleylacetoacetate isomerase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      87192102..87211497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515474.4 → XP_006515537.1  maleylacetoacetate isomerase isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VNC1, Q9JJA0
      Conserved Domains (1) summary
      TIGR01262
      Location:1 → 156
      maiA; maleylacetoacetate isomerase

    2. XM_006515475.2 → XP_006515538.1  maleylacetoacetate isomerase isoform X1

      UniProtKB/TrEMBL
      A0A1Y7VNC1, Q9JJA0
      Conserved Domains (1) summary
      TIGR01262
      Location:1 → 156
      maiA; maleylacetoacetate isomerase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVL0.1 GenPept UniProtKB/Swiss-Prot:Q9WVL0

    Gene LinkOut

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