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    Rai14 retinoic acid induced 14 [ Mus musculus (house mouse) ]

    Gene ID: 75646, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rai14provided by MGI
    Official Full Name
    retinoic acid induced 14provided by MGI
    Primary source
    MGI:MGI:1922896
    See related
    Ensembl:ENSMUSG00000022246 AllianceGenome:MGI:1922896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Norpeg; mKIAA1334; Ankycorbin; 1700008J19Rik; 1700020L11Rik
    Summary
    Predicted to be involved in cell differentiation and spermatogenesis. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; jaw; neural ectoderm; and retina. Orthologous to human RAI14 (retinoic acid induced 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 20.4), CNS E11.5 (RPKM 13.8) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rai14 in Genome Data Viewer
    Location:
    15 A1; 15 5.35 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10569057..10719353, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10568971..10719267, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37954 Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene STARR-seq mESC enhancer starr_37955 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 10389 Neighboring gene RIKEN cDNA 4930556M19 gene Neighboring gene predicted gene, 52214 Neighboring gene STARR-seq mESC enhancer starr_37980 Neighboring gene STARR-seq mESC enhancer starr_37983 Neighboring gene predicted gene, 19276 Neighboring gene predicted gene, 29742

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors. Kim SJ, et al. Elife, 2022 Apr 25. PMID 35467532, Free PMC Article
    2. Retinoic Acid Induced Protein 14 (Rai14) is dispensable for mouse spermatogenesis. Wu Y, et al. PeerJ, 2021. PMID 33643708, Free PMC Article
    3. Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells. Kutty RK, et al. Neurosci Lett, 2006 Sep 1. PMID 16806700
    4. Retinoic acid-induced protein 14 links mechanical forces to Hippo signaling. Jeong W, et al. EMBO Rep, 2024 Sep. PMID 39160347, Free PMC Article
    5. Molecular characterization and developmental expression of NORPEG, a novel gene induced by retinoic acid. Kutty RK, et al. J Biol Chem, 2001 Jan 26. PMID 11042181

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankycorbin
    Names
    NORPEG-like protein
    ankyrin repeat and coiled-coil structure-containing protein
    novel retinal pigment epithelial cell protein
    p125
    retinoic acid-induced protein 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166408.2 → NP_001159880.1  ankycorbin isoform 1

      See identical proteins and their annotated locations for NP_001159880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158921
      Consensus CDS
      CCDS37043.1
      UniProtKB/Swiss-Prot
      Q3URT3, Q6ZPT6, Q9EP71
      Related
      ENSMUSP00000126325.2, ENSMUST00000169385.3
      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:431 → 898
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    2. NM_001356534.2 → NP_001343463.1  ankycorbin isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC158921
      Consensus CDS
      CCDS88734.1
      UniProtKB/TrEMBL
      A0A2I3BPY7
      Related
      ENSMUSP00000153969.2, ENSMUST00000227506.2
      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:402 → 869
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    3. NM_030690.4 → NP_109615.1  ankycorbin isoform 1

      See identical proteins and their annotated locations for NP_109615.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158921
      Consensus CDS
      CCDS37043.1
      UniProtKB/Swiss-Prot
      Q3URT3, Q6ZPT6, Q9EP71
      Related
      ENSMUSP00000087815.4, ENSMUST00000090339.11
      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:431 → 898
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      10569057..10719353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520187.2 → XP_006520250.1  ankycorbin isoform X1

      See identical proteins and their annotated locations for XP_006520250.1

      UniProtKB/Swiss-Prot
      Q3URT3, Q6ZPT6, Q9EP71
      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:431 → 898
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_030248808.1 → XP_030104668.1  ankycorbin isoform X2

      UniProtKB/TrEMBL
      A0A2I3BPY7
      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:402 → 869
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_006520188.5 → XP_006520251.1  ankycorbin isoform X1

      See identical proteins and their annotated locations for XP_006520251.1

      UniProtKB/Swiss-Prot
      Q3URT3, Q6ZPT6, Q9EP71
      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:431 → 898
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_006520190.4 → XP_006520253.1  ankycorbin isoform X2

      UniProtKB/TrEMBL
      A0A2I3BPY7
      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:402 → 869
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_006520192.4 → XP_006520255.1  ankycorbin isoform X3

      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:373 → 840
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_017316775.2 → XP_017172264.1  ankycorbin isoform X1

      UniProtKB/Swiss-Prot
      Q3URT3, Q6ZPT6, Q9EP71
      Conserved Domains (4) summary
      PHA03095
      Location:12 → 224
      PHA03095; ankyrin-like protein; Provisional
      COG1196
      Location:431 → 898
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00045
      Location:118 → 149
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:90 → 182
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EP71.1 GenPept UniProtKB/Swiss-Prot:Q9EP71

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