Adcy6 adenylate cyclase 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adcy6provided by MGI
Official Full Name: adenylate cyclase 6provided by MGI
Primary source: MGI:MGI:87917
See related: Ensembl:ENSMUSG00000022994 AllianceGenome:MGI:87917
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AC6; mKIAA0422
Summary: Enables calcium- and calmodulin-responsive adenylate cyclase activity and scaffold protein binding activity. Involved in several processes, including cAMP biosynthetic process; cellular response to forskolin; and cellular response to vasopressin. Located in plasma membrane. Is expressed in several structures, including adipose tissue; alimentary system; brain; cardiovascular system; and genitourinary system. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human ADCY6 (adenylate cyclase 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 45.5), thymus adult (RPKM 39.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.59 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98484982..98508119, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98589978..98610287, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.
Title: Adenylyl cyclase 6 plays a minor role in the mouse inner ear and retina.
AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals.
Title: AC6 regulates the microtubule-depolymerizing kinesin KIF19A to control ciliary length in mammals.
Purbeta promotes hepatic glucose production by increasing Adcy6 transcription.
Title: Purβ promotes hepatic glucose production by increasing Adcy6 transcription.
Cholera toxin-induced fluid accumulation in vivo was completely absent in AC6 knockout mice mice, associated with a lack of forskolin.
Title: Adenylyl Cyclase 6 Expression Is Essential for Cholera Toxin-Induced Diarrhea.
AC6 is tightly regulated by intrinsic receptor-independent Gi activity.
Title: Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.
Authors demonstrate that this mechanosignalling is dependent on the primary cilium and the ciliary localised adenylyl cyclase 6.
Title: Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium.
Under baseline conditions, renal adenylate cyclase 6 (AC6) is redundant for acid-base balance but becomes important under alkaline conditions.
Title: Adenylyl cyclase 6 is required for maintaining acid-base homeostasis.
AC6 has a minor role in lithium-induced nephrogenic diabetes insipidus development but may be important for determining the intercalated cell-to-principal cell ratio.
Title: Role of adenylyl cyclase 6 in the development of lithium-induced nephrogenic diabetes insipidus.
Immunofluorescence staining revealed that cardiac AC6 was mainly anchored on the sarcolemmal membranes, while AC6-DeltaN was redistributed to the sarcoplasmic reticulum. AC6(DeltaN/DeltaN) and AC6(-/-) mice had more apoptotic myocytes and cardiac remodeling than WT mice in experimental models of isoproterenol (ISO)-induced myocardial injury.
Title: The type VI adenylyl cyclase protects cardiomyocytes from β-adrenergic stress by a PKA/STAT3-dependent pathway.
GluN2B-dependent calcium signaling and excitatory postsynaptic current, long-term depression, and spatial reversal learning are enhanced in the hippocampus of AC6(-/-) mice without altering the gross anatomy of the brain
Title: Type VI adenylyl cyclase negatively regulates GluN2B-mediated LTD and spatial reversal learning.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M93422 (e-PCR)
- UniSTS:125001

R74960 (e-PCR)
- UniSTS:125528

RH125612 (e-PCR)
- UniSTS:162426

D15Bwg0340e (e-PCR), detects polymorphism
- UniSTS:142003

M93422 (e-PCR)
- UniSTS:163561

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables calcium- and calmodulin-responsive adenylate cyclase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium- and calmodulin-responsive adenylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in blood vessel diameter maintenance	ISO Inferred from Sequence Orthology more info
involved_in cAMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to catecholamine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to forskolin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to forskolin	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin E stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to vasopressin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal water homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in microvillus membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in stereocilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylate cyclase type 6

Names: ATP pyrophosphate-lyase 6; adenylate cyclase type VI; adenylyl cyclase 6; ca(2+)-inhibitable adenylyl cyclase

NP_001355342.1

EC 4.6.1.1

NP_001397290.1

EC 4.6.1.1

NP_001397291.1

EC 4.6.1.1

NP_001397292.1

EC 4.6.1.1

NP_001397293.1

EC 4.6.1.1

NP_001397294.1

EC 4.6.1.1

NP_001397295.1

EC 4.6.1.1

NP_001397296.1

EC 4.6.1.1

NP_001397297.1

EC 4.6.1.1

XP_006520366.3

EC 4.6.1.1

XP_036014969.1

EC 4.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368413.2 → NP_001355342.1 adenylate cyclase type 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC138221

Consensus CDS

CCDS88833.1

UniProtKB/TrEMBL

A0A2I3BRC5, F8VQ52

Related

ENSMUSP00000093939.5, ENSMUST00000096224.6

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:14 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)
NM_001410361.1 → NP_001397290.1 adenylate cyclase type 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC138221

UniProtKB/TrEMBL

A0A2I3BRC5, F8VQ52
NM_001410362.1 → NP_001397291.1 adenylate cyclase type 6 isoform 3

Status: VALIDATED

Source sequence(s)

AC138221

UniProtKB/TrEMBL

F8VQ52
NM_001410363.1 → NP_001397292.1 adenylate cyclase type 6 isoform 4

Status: VALIDATED

Source sequence(s)

AC138221

UniProtKB/TrEMBL

F8VQ52
NM_001410364.1 → NP_001397293.1 adenylate cyclase type 6 isoform 2

Status: VALIDATED

Source sequence(s)

AC138221

UniProtKB/TrEMBL

A0A2I3BRC5, F8VQ52
NM_001410365.1 → NP_001397294.1 adenylate cyclase type 6 isoform 5

Status: VALIDATED

Source sequence(s)

AC138221

UniProtKB/TrEMBL

F8VQ52
NM_001410366.1 → NP_001397295.1 adenylate cyclase type 6 isoform 6

Status: VALIDATED

Source sequence(s)

AC138221

UniProtKB/TrEMBL

F8VQ52
NM_001410367.1 → NP_001397296.1 adenylate cyclase type 6 isoform 7

Status: VALIDATED

Source sequence(s)

AC138221

UniProtKB/TrEMBL

F8VQ52
NM_001410368.1 → NP_001397297.1 adenylate cyclase type 6 isoform 8

Status: VALIDATED

Source sequence(s)

AC138221

UniProtKB/TrEMBL

F8VQ52

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

98484982..98508119 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520303.5 → XP_006520366.3 adenylate cyclase type 6 isoform X1

UniProtKB/TrEMBL

F8VQ52

Conserved Domains (3) summary

pfam00211
Location:1056 → 1250

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:83 → 454

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:668 → 754

DUF1053; Domain of Unknown Function (DUF1053)
XM_036159076.1 → XP_036014969.1 adenylate cyclase type 6 isoform X5

UniProtKB/TrEMBL

A0A2I3BRC5, F8VQ52

Related

ENSMUSP00000154421.2, ENSMUST00000228566.2

Conserved Domains (3) summary

pfam00211
Location:968 → 1162

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

pfam16214
Location:14 → 366

AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

pfam06327
Location:580 → 666

DUF1053; Domain of Unknown Function (DUF1053)

RNA

XR_004938786.1 RNA Sequence
XR_001781491.3 RNA Sequence
XR_004938785.1 RNA Sequence
XR_383972.5 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_007405.3: Suppressed sequence

Description

NM_007405.3: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.