Myh7b myosin, heavy chain 7B, cardiac muscle, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myh7bprovided by MGI
Official Full Name: myosin, heavy chain 7B, cardiac muscle, betaprovided by MGI
Primary source: MGI:MGI:3710243
See related: Ensembl:ENSMUSG00000074652 AllianceGenome:MGI:3710243
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Myh14
Summary: This gene encodes a myosin heavy chain. The encoded protein forms a hexamer comprised of two heavy chains, two alkali light chains, and two regulatory light chain components. This complex functions in muscle contraction. [provided by RefSeq, Jun 2013]
Expression: Biased expression in heart adult (RPKM 6.9), limb E14.5 (RPKM 3.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.26 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (155453129..155476227)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (155611243..155634307)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MyoD and Eos form an active transcriptional complex on the chromatin to regulate the expression of the endogenous Myh7b/miR-499 gene in muscle cells.
Title: Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos.
Myh7b, the ortholog of slow myosin 2 (SM2) of frogs and birds, is detected as mRNA in heart, slow muscles and extraocular muscles. MYH7b protein is detected only in a minor fiber population in extraocular muscles, corresponding to slow-tonic fibers.
Title: Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Mit494 (e-PCR), detects polymorphism
- UniSTS:129412

RH126268 (e-PCR)
- UniSTS:162976

Myh7b (e-PCR), detects polymorphism
- UniSTS:530877

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of CAMKK-AMPK signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of CAMKK-AMPK signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	IEA Inferred from Electronic Annotation more info
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cardiac myofibril	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: myosin-7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085378.2 → NP_001078847.1 myosin-7B

Status: REVIEWED

Source sequence(s)

AL844852

Consensus CDS

CCDS50768.1

UniProtKB/Swiss-Prot

A2AQP0

Related

ENSMUSP00000090672.6, ENSMUST00000092995.6

Conserved Domains (6) summary

cd14927
Location:98 → 773

MYSc_Myh7b; class II myosin heavy chain 7b, motor domain

pfam00063
Location:87 → 773

Myosin_head; Myosin head (motor domain)

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 71

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1819 → 1830

GBP_C; coiled coil [structural motif]

cl20817
Location:1749 → 1830

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

155453129..155476227

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162500.1 → XP_036018393.1 myosin-7B isoform X7

Conserved Domains (2) summary

pfam01576
Location:624 → 1701

Myosin_tail_1; Myosin tail

cl22853
Location:1 → 544

Motor_domain; Myosin and Kinesin motor domain
XM_017319211.3 → XP_017174700.1 myosin-7B isoform X8

Conserved Domains (3) summary

cd14927
Location:98 → 773

MYSc_Myh7b; class II myosin heavy chain 7b, motor domain

pfam01576
Location:853 → 1930

Myosin_tail_1; Myosin tail

pfam02736
Location:32 → 71

Myosin_N; Myosin N-terminal SH3-like domain
XM_017319206.3 → XP_017174695.1 myosin-7B isoform X1

Conserved Domains (2) summary

cl22853
Location:13 → 569

Motor_domain; Myosin and Kinesin motor domain

pfam01576
Location:649 → 1653

Myosin_tail_1; Myosin tail
XM_017319208.3 → XP_017174697.1 myosin-7B isoform X3

Conserved Domains (2) summary

cl22853
Location:13 → 569

Motor_domain; Myosin and Kinesin motor domain

pfam01576
Location:649 → 1625

Myosin_tail_1; Myosin tail
XM_017319207.3 → XP_017174696.1 myosin-7B isoform X2

Conserved Domains (2) summary

cl22853
Location:1 → 544

Motor_domain; Myosin and Kinesin motor domain

pfam01576
Location:624 → 1628

Myosin_tail_1; Myosin tail
XM_017319210.3 → XP_017174699.1 myosin-7B isoform X5

Conserved Domains (2) summary

cl22853
Location:1 → 471

Motor_domain; Myosin and Kinesin motor domain

pfam01576
Location:551 → 1555

Myosin_tail_1; Myosin tail
XM_006500047.5 → XP_006500110.1 myosin-7B isoform X2

Conserved Domains (2) summary

cl22853
Location:1 → 544

Motor_domain; Myosin and Kinesin motor domain

pfam01576
Location:624 → 1628

Myosin_tail_1; Myosin tail
XM_017319209.3 → XP_017174698.1 myosin-7B isoform X4

Conserved Domains (2) summary

cl22853
Location:13 → 569

Motor_domain; Myosin and Kinesin motor domain

pfam01576
Location:649 → 1754

Myosin_tail_1; Myosin tail
XM_036162499.1 → XP_036018392.1 myosin-7B isoform X6

Conserved Domains (2) summary

pfam01576
Location:649 → 1726

Myosin_tail_1; Myosin tail

cl22853
Location:13 → 569

Motor_domain; Myosin and Kinesin motor domain