Cwh43 cell wall biogenesis 43 C-terminal homolog [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cwh43provided by MGI
Official Full Name: cell wall biogenesis 43 C-terminal homologprovided by MGI
Primary source: MGI:MGI:2444131
See related: Ensembl:ENSMUSG00000029154 AllianceGenome:MGI:2444131
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: imds-60; C130090K23Rik
Summary: Acts upstream of or within several processes, including cerebrospinal fluid circulation; establishment of protein localization; and protein N-linked glycosylation. Predicted to be located in extracellular region and membrane. Predicted to be active in endoplasmic reticulum. Is expressed in head mesenchyme and otic capsule. Used to study normal pressure hydrocephalus. Orthologous to human CWH43 (cell wall biogenesis 43 C-terminal homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 18.2), stomach adult (RPKM 13.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 C3.3; 5 38.78 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (73563394..73610778)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (73406051..73453435)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus.
Title: Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus.
The imds-60 protein might play an important role in cell communication during sperm maturation.
Title: Identification of the gene imds-60 in mouse epididymis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebrospinal fluid circulation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane protein proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to extracellular region	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PGAP2-interacting protein

Names: cell wall biogenesis protein 43 C-terminal homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418155.1 → NP_001405084.1 PGAP2-interacting protein isoform 2

Status: VALIDATED

Source sequence(s)

AC108828, AC134551

Related

ENSMUSP00000069563.7, ENSMUST00000065543.8
NM_181323.3 → NP_851840.1 PGAP2-interacting protein isoform 1

See identical proteins and their annotated locations for NP_851840.1

Status: VALIDATED

Source sequence(s)

AC108828, AC134551

Consensus CDS

CCDS19341.1

UniProtKB/Swiss-Prot

Q8CBQ1, Q91YL7

Related

ENSMUSP00000031040.7, ENSMUST00000031040.13

Conserved Domains (1) summary

pfam03372
Location:451 → 580

Exo_endo_phos; Endonuclease/Exonuclease/phosphatase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

73563394..73610778

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017320839.2 → XP_017176328.1 PGAP2-interacting protein isoform X1

Conserved Domains (1) summary

cl00490
Location:443 → 597

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
XM_006503949.3 → XP_006504012.1 PGAP2-interacting protein isoform X2

Conserved Domains (1) summary

cl00490
Location:354 → 493

EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
XM_006503950.5 → XP_006504013.1 PGAP2-interacting protein isoform X3