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    A430033K04Rik RIKEN cDNA A430033K04 gene [ Mus musculus (house mouse) ]

    Gene ID: 243308, updated on 9-Dec-2024

    Summary

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    Official Symbol
    A430033K04Rikprovided by MGI
    Official Full Name
    RIKEN cDNA A430033K04 geneprovided by MGI
    Primary source
    MGI:MGI:3583896
    See related
    Ensembl:ENSMUSG00000056014 AllianceGenome:MGI:3583896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ObI1; ObI-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in regulation of osteoblast differentiation. Acts upstream of or within negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 4.7), CNS E18 (RPKM 4.4) and 23 other tissues See more
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    Genomic context

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    See A430033K04Rik in Genome Data Viewer
    Location:
    5 G2; 5 77.1 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138621121..138647179)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138622859..138648917)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700123K08 gene Neighboring gene STARR-seq mESC enhancer starr_14669 Neighboring gene STARR-positive B cell enhancer ABC_E1314 Neighboring gene zinc finger protein 68 Neighboring gene STARR-seq mESC enhancer starr_14671 Neighboring gene STARR-seq mESC enhancer starr_14672 Neighboring gene STARR-seq mESC enhancer starr_14673 Neighboring gene FAM20C, golgi associated secretory pathway kinase Neighboring gene STARR-seq mESC enhancer starr_14674 Neighboring gene forkhead box L3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of a Novel Transcription Factor Required for Osteogenic Differentiation of Mesenchymal Stem Cells. Querques F, et al. Stem Cells Dev, 2019 Mar 15. PMID 30654721
    2. Identification and characterization of reproductive KRAB-ZF genes in mice. Jin S, et al. Gene, 2015 Jul 1. PMID 25827285
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein OBI1
    Names
    osteoblast inducer-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183025.2 → NP_898846.2  zinc finger protein OBI1

      Status: VALIDATED

      Source sequence(s)
      AI842993, AK009353, BC055299, BM229635
      UniProtKB/Swiss-Prot
      E9Q8G5
      Related
      ENSMUSP00000067316.8, ENSMUST00000069862.11
      Conserved Domains (4) summary
      smart00349
      Location:16 → 75
      KRAB; krueppel associated box
      COG5048
      Location:261 → 670
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:513 → 533
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:429 → 449
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138621121..138647179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9Q8G5.1 GenPept UniProtKB/Swiss-Prot:E9Q8G5

    Gene LinkOut

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