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    Ece1 endothelin converting enzyme 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94204, updated on 4-Jan-2025

    Summary

    Official Symbol
    Ece1provided by RGD
    Official Full Name
    endothelin converting enzyme 1provided by RGD
    Primary source
    RGD:620293
    See related
    EnsemblRapid:ENSRNOG00000014241 AllianceGenome:RGD:620293
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ece
    Summary
    Enables identical protein binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; and regulation of signal transduction. Located in early endosome; external side of plasma membrane; and secretory granule. Used to study acute kidney failure; congestive heart failure; hyperhomocysteinemia; hypertension; and pulmonary hypertension. Biomarker of acute kidney failure; congestive heart failure; hypertension; nephrotic syndrome; and renal fibrosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Adrenal (RPKM 436.7), Lung (RPKM 390.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ece1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155361031..155462723)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150077679..150179375)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156215469..156318652)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase, biomineralization associated Neighboring gene uncharacterized LOC134487019 Neighboring gene U4 spliceosomal RNA Neighboring gene eukaryotic translation initiation factor 4 gamma, 3 Neighboring gene uncharacterized LOC102553758 Neighboring gene uncharacterized LOC134487020

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity  
    enables identical protein binding PubMed 
    enables metal ion binding  
    enables metalloendopeptidase activity  
    enables metalloendopeptidase activity  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables zinc ion binding  
    enables zinc ion binding  
    Items 1 - 25 of 45
    Process Evidence Code Pubs
    involved_in axon guidance  
    involved_in axonogenesis involved in innervation  
    involved_in axonogenesis involved in innervation  
    involved_in blood vessel diameter maintenance PubMed 
    involved_in bradykinin catabolic process  
    involved_in bradykinin catabolic process  
    involved_in calcitonin catabolic process  
    involved_in calcitonin catabolic process  
    involved_in ear development  
    involved_in ear development  
    involved_in embryonic digit morphogenesis  
    involved_in embryonic digit morphogenesis  
    involved_in embryonic heart tube development  
    involved_in embryonic heart tube development  
    involved_in endothelin maturation  
    involved_in endothelin maturation  
    involved_in gene expression  
    involved_in heart development  
    involved_in hormone catabolic process  
    involved_in neuron projection development  
    involved_in peptide hormone processing  
    involved_in peptide hormone processing  
    involved_in pharyngeal system development  
    acts_upstream_of_or_within pharyngeal system development  
    involved_in positive regulation of G protein-coupled receptor signaling pathway PubMed 
    involved_in positive regulation of cAMP/PKA signal transduction PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy PubMed 
    involved_in positive regulation of receptor recycling  
    involved_in positive regulation of receptor recycling PubMed 
    involved_in positive regulation of receptor recycling  
    involved_in protein processing PubMed 
    involved_in protein processing  
    involved_in proteolysis  
    involved_in regulation of ERK1 and ERK2 cascade PubMed 
    involved_in regulation of blood pressure PubMed 
    involved_in response to cadmium ion PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to muscle stretch PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in semaphorin-plexin signaling pathway involved in axon guidance  
    involved_in semaphorin-plexin signaling pathway involved in axon guidance  
    involved_in substance P catabolic process  
    involved_in substance P catabolic process  
    involved_in sympathetic neuron axon guidance  
    involved_in sympathetic neuron axon guidance  
    Items 1 - 25 of 45
    Component Evidence Code Pubs
    located_in Weibel-Palade body  
    located_in Weibel-Palade body  
    located_in early endosome PubMed 
    located_in early endosome  
    located_in endosome  
    located_in endosome  
    located_in external side of plasma membrane PubMed 
    located_in external side of plasma membrane  
    located_in external side of plasma membrane  
    located_in membrane  
    located_in perinuclear region of cytoplasm  
    located_in perinuclear region of cytoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    located_in secretory granule PubMed 
    located_in vesicle PubMed 

    General protein information

    Preferred Names
    endothelin-converting enzyme 1
    Names
    ECE-1
    NP_446048.2
    XP_006239337.1
    XP_006239338.1
    XP_063144586.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053596.2NP_446048.2  endothelin-converting enzyme 1

      See identical proteins and their annotated locations for NP_446048.2

      Status: PROVISIONAL

      Source sequence(s)
      BC072504
      UniProtKB/TrEMBL
      A0A0G2K465, A0A8I6AMF9, A6ITF1, F7EP67, Q6IN10
      Related
      ENSRNOP00000072923.1, ENSRNOT00000077742.3
      Conserved Domains (2) summary
      cd08662
      Location:103752
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:90754
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      155361031..155462723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288516.1XP_063144586.1  endothelin-converting enzyme 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AMF9
    2. XM_006239275.5XP_006239337.1  endothelin-converting enzyme 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AL15, A0A8I6AMF9
      Related
      ENSRNOP00000093768.1, ENSRNOT00000108805.2
      Conserved Domains (2) summary
      cd08662
      Location:118767
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:105769
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    3. XM_006239276.5XP_006239338.1  endothelin-converting enzyme 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJE5, A0A8J8Y3G8
      Related
      ENSRNOP00000095338.2, ENSRNOT00000096331.2
      Conserved Domains (2) summary
      cd08662
      Location:84733
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:71735
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
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