Fbxl2 F-box and leucine-rich repeat protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fbxl2provided by MGI
Official Full Name: F-box and leucine-rich repeat protein 2provided by MGI
Primary source: MGI:MGI:1919429
See related: Ensembl:ENSMUSG00000032507 AllianceGenome:MGI:1919429
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fbl3; 2810423A21Rik
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and regulation of inflammatory response. Acts upstream of or within protein monoubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human FBXL2 (F-box and leucine rich repeat protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in cortex adult (RPKM 11.6), CNS E18 (RPKM 10.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 64.17 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (113787625..113855871, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (113958557..114026803, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-alpha during Acute and Chronic Lung Allograft Rejection.
Title: Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-α during Acute and Chronic Lung Allograft Rejection.
Study demonstrated that TRAF6 plays an important role in the process of aseptic inflammatory loosening caused by periprosthetic debris, and Low intensity pulsed ultrasound was found to inhibit such inflammation through increasing the level of FBXL2, and further increasing ubiquitination of TRAF6.
Title: Low-intensity pulsed ultrasound (LIPUS) prevents periprosthetic inflammatory loosening through FBXL2-TRAF6 ubiquitination pathway.
FBXL2 mediates Aurora B ubiquitination and degradation within the midbody, which is sufficient to induce mitotic arrest and apoptosis.
Title: Skp-cullin-F box E3 ligase component FBXL2 ubiquitinates Aurora B to inhibit tumorigenesis.
FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.
Title: FBXL2 is a ubiquitin E3 ligase subunit that triggers mitotic arrest.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in modulation by host of viral RNA genome replication	IEA Inferred from Electronic Annotation more info
involved_in modulation by host of viral RNA genome replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein monoubiquitination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein monoubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: F-box/LRR-repeat protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178624.7 → NP_848739.1 F-box/LRR-repeat protein 2

See identical proteins and their annotated locations for NP_848739.1

Status: VALIDATED

Source sequence(s)

CT025531

Consensus CDS

CCDS40790.1

UniProtKB/Swiss-Prot

Q8BH16, Q8BXM4

UniProtKB/TrEMBL

Q3TQM5, Q4VA21

Related

ENSMUSP00000035090.8, ENSMUST00000035090.14

Conserved Domains (3) summary

cd09293
Location:168 → 367

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:106 → 131

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:15 → 57

F-box-like; F-box-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

113787625..113855871 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244622.1 → XP_030100482.1 F-box/LRR-repeat protein 2 isoform X3

Conserved Domains (2) summary

cd09293
Location:63 → 262

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:27 → 52

LRR_AMN1; leucine-rich repeat [structural motif]
XM_030244623.2 → XP_030100483.1 F-box/LRR-repeat protein 2 isoform X3

Conserved Domains (2) summary

cd09293
Location:63 → 262

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:27 → 52

LRR_AMN1; leucine-rich repeat [structural motif]
XM_011243027.3 → XP_011241329.1 F-box/LRR-repeat protein 2 isoform X3

See identical proteins and their annotated locations for XP_011241329.1

Conserved Domains (2) summary

cd09293
Location:63 → 262

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:27 → 52

LRR_AMN1; leucine-rich repeat [structural motif]
XM_036155307.1 → XP_036011200.1 F-box/LRR-repeat protein 2 isoform X2

Conserved Domains (3) summary

cd09293
Location:80 → 275

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:106 → 131

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:15 → 56

F-box-like
XM_036155306.1 → XP_036011199.1 F-box/LRR-repeat protein 2 isoform X1

Conserved Domains (3) summary

cd09293
Location:80 → 275

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:52 → 79

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:15 → 56

F-box-like
XM_006512295.3 → XP_006512358.1 F-box/LRR-repeat protein 2 isoform X4

Conserved Domains (3) summary

cd09293
Location:80 → 275

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:52 → 79

LRR_AMN1; leucine-rich repeat [structural motif]

pfam12937
Location:15 → 56

F-box-like