Otud6a OTU domain containing 6A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Otud6aprovided by MGI
Official Full Name: OTU domain containing 6Aprovided by MGI
Primary source: MGI:MGI:3644685
See related: Ensembl:ENSMUSG00000051582 AllianceGenome:MGI:3644685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hshin6; EG408193
Summary: Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in protein deubiquitination. Orthologous to human OTUD6A (OTU deubiquitinase 6A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: X C3; X 43.72 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (99472514..99474859)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (100428908..100429885)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING.
Title: Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING.
OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3.
Title: OTUD6A in tubular epithelial cells mediates angiotensin II-induced kidney injury by targeting STAT3.
Deubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13.
Title: Deubiquitinase OTUD6A Regulates Innate Immune Response via Targeting UBC13.
Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3.
Title: Deubiquitinase OTUD6A in macrophages promotes intestinal inflammation and colitis via deubiquitination of NLRP3.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein K11-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K11-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K27-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K27-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K29-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K29-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K33-linked deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein K33-linked deubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: OTU domain-containing protein 6A

Names: Hin-6 protease

NP_001156663.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163191.3 → NP_001156663.1 OTU domain-containing protein 6A

See identical proteins and their annotated locations for NP_001156663.1

Status: VALIDATED

Source sequence(s)

AL671299

Consensus CDS

CCDS53146.1

UniProtKB/Swiss-Prot

A2ADU1, A8E630, Q6IE21

Related

ENSMUSP00000059861.3, ENSMUST00000060241.3

Conserved Domains (2) summary

COG5539
Location:5 → 272

COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]

pfam02338
Location:148 → 270

OTU; OTU-like cysteine protease