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    P22k15 cystatin related protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296229, updated on 9-Dec-2024

    Summary

    Symbol
    P22k15provided by RGD
    Full Name
    cystatin related protein 2provided by RGD
    Primary source
    RGD:727814
    See related
    EnsemblRapid:ENSRNOG00000030184 AllianceGenome:RGD:727814
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crp2
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be active in cytoplasm; extracellular space; and vesicle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 4.0) and Brain (RPKM 0.5) See more
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    Genomic context

    See P22k15 in Genome Data Viewer
    Location:
    3q41
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (157420930..157427988, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (136960300..136967358, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (143426001..143430075, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1, pseudogene 6 Neighboring gene ferritin heavy chain 1, pseudogene 5 Neighboring gene dipeptidylpeptidase 3 like 1 Neighboring gene eukaryotic translation initiation factor 1 like 1 Neighboring gene cystatin 2 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cystatin-related protein 2
    Names
    prostatic 22 kDa glycoprotein P22K15
    prostatic 22-kD glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199266.2NP_954887.1  cystatin-related protein 2 precursor

      See identical proteins and their annotated locations for NP_954887.1

      Status: PROVISIONAL

      Source sequence(s)
      BC100632
      UniProtKB/Swiss-Prot
      P22283, Q497B4
      UniProtKB/TrEMBL
      A6K7E9, Z4YNX7
      Related
      ENSRNOP00000043921.6, ENSRNOT00000050369.7
      Conserved Domains (2) summary
      cd00042
      Location:41135
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
      cl09238
      Location:117174
      CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      157420930..157427988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)