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    Sephs2 selenophosphate synthetase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308993, updated on 27-Nov-2024

    Summary

    Official Symbol
    Sephs2provided by RGD
    Official Full Name
    selenophosphate synthetase 2provided by RGD
    Primary source
    RGD:1308827
    See related
    AllianceGenome:RGD:1308827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. [provided by RefSeq, May 2017]
    Orthologs
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    Genomic context

    See Sephs2 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191323637..191325955, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181893146..181895464, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198719158..198721476, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 771 Neighboring gene dCTP pyrophosphatase 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit A13, pseudogene 4 Neighboring gene ankyrin repeat domain 37, pseudogene 1

    Genomic regions, transcripts, and products

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC156840

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables selenide, water dikinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables selenide, water dikinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within selenium compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in selenocysteine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within selenocysteine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    selenide, water dikinase 2
    NP_001073358.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079889.2NP_001073358.2  selenide, water dikinase 2

      Status: REVIEWED

      Source sequence(s)
      BC097429
      Conserved Domains (2) summary
      cd02195
      Location:53409
      SelD; Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The ...
      TIGR00476
      Location:52385
      selD; selenium donor protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191323637..191325955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)