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    Prkacb protein kinase cAMP-activated catalytic subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293508, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prkacbprovided by RGD
    Official Full Name
    protein kinase cAMP-activated catalytic subunit betaprovided by RGD
    Primary source
    RGD:1310574
    See related
    EnsemblRapid:ENSRNOG00000004978 AllianceGenome:RGD:1310574
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables cAMP-dependent protein kinase activity. Involved in negative regulation of meiotic cell cycle and protein phosphorylation. Located in perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Biomarker of brain ischemia. Orthologous to human PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 561.4), Adrenal (RPKM 229.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Prkacb in Genome Data Viewer
    Location:
    2q44
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (238297140..238389317, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235636878..235726928, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252602197..252691886, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100966 Neighboring gene uncharacterized LOC134485994 Neighboring gene tubulin tyrosine ligase like 7 Neighboring gene uncharacterized LOC108350293

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cAMP-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cAMP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cAMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cAMP-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP-dependent protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase A regulatory subunit binding IC
    Inferred by Curator
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of meiotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neural tube closure IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cAMP-dependent protein kinase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ciliary base IEA
    Inferred from Electronic Annotation
    more info
     
    located_in ciliary base ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    cAMP-dependent protein kinase catalytic subunit beta
    Names
    PKA C-beta
    protein kinase, cAMP dependent, catalytic, beta
    protein kinase, cAMP-dependent, beta catalytic subunit
    NP_001071113.1
    XP_006233513.1
    XP_006233514.1
    XP_006233515.1
    XP_038957812.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077645.1NP_001071113.1  cAMP-dependent protein kinase catalytic subunit beta

      See identical proteins and their annotated locations for NP_001071113.1

      Status: PROVISIONAL

      Source sequence(s)
      D10770
      UniProtKB/Swiss-Prot
      P68182
      UniProtKB/TrEMBL
      A0A8I6GBC1, A6HWE9
      Related
      ENSRNOP00000062228.1, ENSRNOT00000068739.3
      Conserved Domains (1) summary
      cd14209
      Location:42331
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      238297140..238389317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233451.5XP_006233513.1  cAMP-dependent protein kinase catalytic subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006233513.1

      UniProtKB/TrEMBL
      A0A8I6A4F6, A0A8I6GBC1, A6HWF0
      Related
      ENSRNOP00000086804.1, ENSRNOT00000119887.2
      Conserved Domains (2) summary
      PTZ00263
      Location:79398
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd14209
      Location:89378
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    2. XM_006233452.5XP_006233514.1  cAMP-dependent protein kinase catalytic subunit beta isoform X2

      See identical proteins and their annotated locations for XP_006233514.1

      UniProtKB/TrEMBL
      A0A8I6GBC1, A6HWF1
      Related
      ENSRNOP00000109470.1, ENSRNOT00000127717.1
      Conserved Domains (1) summary
      cd14209
      Location:30319
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    3. XM_006233453.5XP_006233515.1  cAMP-dependent protein kinase catalytic subunit beta isoform X3

      See identical proteins and their annotated locations for XP_006233515.1

      UniProtKB/TrEMBL
      A0A8I6AV42, A6HWF2, Q05759
      Related
      ENSRNOP00000092040.1, ENSRNOT00000117576.2
      Conserved Domains (1) summary
      cd14209
      Location:29318
      STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
    4. XM_039101884.2XP_038957812.2  cAMP-dependent protein kinase catalytic subunit beta isoform X4