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    Prkd3 protein kinase D3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313834, updated on 3-Dec-2024

    Summary

    Official Symbol
    Prkd3provided by RGD
    Official Full Name
    protein kinase D3provided by RGD
    Primary source
    RGD:1310236
    See related
    EnsemblRapid:ENSRNOG00000005289 AllianceGenome:RGD:1310236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prkcn
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and phospholipase C-activating G protein-coupled receptor signaling pathway. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 318.5), Lung (RPKM 232.7) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Prkd3 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21784665..21860600)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16032507..16108444)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1546018..1622232, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene glutaminyl-peptide cyclotransferase Neighboring gene ribosomal protein S17, pseudogene 9 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene CCAAT/enhancer binding protein zeta Neighboring gene CEBPZ opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase D3
    Names
    protein kinase C, nu
    NP_001019434.2
    XP_006239691.1
    XP_006239693.1
    XP_038968056.1
    XP_038968057.1
    XP_063117874.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024263.2NP_001019434.2  serine/threonine-protein kinase D3

      See identical proteins and their annotated locations for NP_001019434.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6G5U2, D4A229
      Conserved Domains (4) summary
      cd01239
      Location:410534
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:572831
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:145219
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:267335
      C1; protein kinase C conserved region 1 (C1 domain) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      21784665..21860600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112129.2XP_038968057.1  serine/threonine-protein kinase D3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G5U2
      Related
      ENSRNOP00000079860.1, ENSRNOT00000095865.2
      Conserved Domains (4) summary
      cd01239
      Location:306430
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:468727
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:41115
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:163231
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    2. XM_039112128.2XP_038968056.1  serine/threonine-protein kinase D3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5U2, D4A229
      Conserved Domains (4) summary
      cd01239
      Location:410534
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:572831
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:145219
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:267335
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    3. XM_006239629.5XP_006239691.1  serine/threonine-protein kinase D3 isoform X1

      See identical proteins and their annotated locations for XP_006239691.1

      UniProtKB/TrEMBL
      A0A8I6G5U2, D4A229
      Related
      ENSRNOP00000007491.4, ENSRNOT00000007492.9
      Conserved Domains (4) summary
      cd01239
      Location:410534
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:572831
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:145219
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:267335
      C1; protein kinase C conserved region 1 (C1 domain) superfamily
    4. XM_063261804.1XP_063117874.1  serine/threonine-protein kinase D3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G5U2, D4A229
    5. XM_006239631.5XP_006239693.1  serine/threonine-protein kinase D3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G5U2
      Conserved Domains (4) summary
      cd01239
      Location:306430
      PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
      cd14082
      Location:468727
      STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
      cd20841
      Location:41115
      C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
      cl00040
      Location:163231
      C1; protein kinase C conserved region 1 (C1 domain) superfamily