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    Lyn LYN proto-oncogene, Src family tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81515, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lynprovided by RGD
    Official Full Name
    LYN proto-oncogene, Src family tyrosine kinaseprovided by RGD
    Primary source
    RGD:621017
    See related
    EnsemblRapid:ENSRNOG00000008180 AllianceGenome:RGD:621017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p53Lyn; p56Lyn
    Summary
    Enables several functions, including gamma-tubulin binding activity; signaling receptor binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including histamine secretion by mast cell; positive regulation of Fc receptor mediated stimulatory signaling pathway; and positive regulation of gliogenesis. Located in adherens junction; mitochondrial crista; and perinuclear region of cytoplasm. Part of integrin alpha2-beta1 complex. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Biomarker of Parkinsonism and endometriosis. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 493.9), Lung (RPKM 314.9) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Lyn in Genome Data Viewer
    Location:
    5q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (21437127..21553097)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (16639512..16755501)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (16526058..16642648)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene trimethylguanosine synthase 1 Neighboring gene sterol carrier protein 2, pseudogene 1 Neighboring gene uncharacterized LOC134486916 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA, C/D box 54 Neighboring gene ribosomal protein S20

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ephrin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glycosphingolipid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables integrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables non-membrane spanning protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol 3-kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphorylation-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables platelet-derived growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in B cell homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in C-X-C chemokine receptor CXCR4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Fc receptor mediated inhibitory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Fc receptor mediated inhibitory signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in Fc receptor mediated stimulatory signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Fc receptor mediated stimulatory signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Fc receptor mediated stimulatory signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within autophagy ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to heat IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dendritic cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dendritic cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in eosinophil differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fatty acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine secretion by mast cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response-regulating cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response-regulating cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in interleukin-5-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipopolysaccharide-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of MAP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of mast cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of mast cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of myeloid leukocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor 2 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of toll-like receptor 2 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of toll-like receptor 4 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within neuroinflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligodendrocyte development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in platelet degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendritic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of glial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mast cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of oligodendrocyte progenitor proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of B cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mast cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mast cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mast cell degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of platelet aggregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of release of sequestered calcium ion into cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to axon injury IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to carbohydrate IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hormone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to insulin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to peptide hormone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to sterol depletion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tolerance induction to self antigen IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tolerance induction to self antigen ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tolerance induction to self antigen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of integrin alpha2-beta1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial crista IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein kinase Lyn
    Names
    Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
    lyn protein non-receptor kinase
    v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
    NP_001104568.1
    NP_110484.1
    XP_006237896.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111098.1NP_001104568.1  tyrosine-protein kinase Lyn isoform B

      See identical proteins and their annotated locations for NP_001104568.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform B).
      Source sequence(s)
      AF000301, JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JFK9
      Conserved Domains (4) summary
      cd10364
      Location:104204
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:46101
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:218489
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
      pfam07714
      Location:226476
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_030857.2NP_110484.1  tyrosine-protein kinase Lyn isoform A

      See identical proteins and their annotated locations for NP_110484.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (A).
      Source sequence(s)
      AF000300, AF000301, JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q07014, Q63320
      UniProtKB/TrEMBL
      A6JFK8
      Related
      ENSRNOP00000011130.4, ENSRNOT00000011130.7
      Conserved Domains (4) summary
      cd10364
      Location:125225
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:67122
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:239510
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
      pfam07714
      Location:247497
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      21437127..21553097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237834.5XP_006237896.1  tyrosine-protein kinase Lyn isoform X1

      See identical proteins and their annotated locations for XP_006237896.1

      UniProtKB/Swiss-Prot
      Q07014, Q63320
      UniProtKB/TrEMBL
      A6JFK8
      Conserved Domains (4) summary
      cd10364
      Location:125225
      SH2_Src_Lyn; Src homology 2 (SH2) domain found in Lyn
      cd12004
      Location:67122
      SH3_Lyn; Src homology 3 domain of Lyn Protein Tyrosine Kinase
      cd05072
      Location:239510
      PTKc_Lyn; Catalytic domain of the Protein Tyrosine Kinase, Lyn
      pfam07714
      Location:247497
      Pkinase_Tyr; Protein tyrosine kinase