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    Gfod2 glucose-fructose oxidoreductase domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 70575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gfod2provided by MGI
    Official Full Name
    glucose-fructose oxidoreductase domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917825
    See related
    Ensembl:ENSMUSG00000013150 AllianceGenome:MGI:1917825
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5730466C23Rik
    Summary
    Predicted to enable nucleotide binding activity and oxidoreductase activity. Acts upstream of or within extracellular matrix organization. Located in extracellular matrix. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human GFOD2 (Gfo/Idh/MocA-like oxidoreductase domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 7.1), CNS E14 (RPKM 6.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gfod2 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106440676..106485299, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105714044..105758666, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3798 Neighboring gene RIKEN cDNA 4933405L10 gene Neighboring gene STARR-positive B cell enhancer ABC_E6678 Neighboring gene par-6 family cell polarity regulator alpha Neighboring gene enkurin domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E8850 Neighboring gene RAN binding protein 10 Neighboring gene STARR-positive B cell enhancer ABC_E2272 Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E2875 Neighboring gene centromere protein T

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
    2. Transcriptome-based systematic identification of extracellular matrix proteins. Manabe R, et al. Proc Natl Acad Sci U S A, 2008 Sep 2. PMID 18757743, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extracellular matrix organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-fructose oxidoreductase domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368385.1 → NP_001355314.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC152826
      Conserved Domains (1) summary
      COG0673
      Location:7 → 404
      MviM; Predicted dehydrogenase [General function prediction only]

    2. NM_001368386.1 → NP_001355315.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC152826
      Consensus CDS
      CCDS22612.1
      UniProtKB/Swiss-Prot
      Q9CYH5
      Conserved Domains (1) summary
      COG0673
      Location:7 → 364
      MviM; Predicted dehydrogenase [General function prediction only]

    3. NM_001368388.1 → NP_001355317.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC152826
      Conserved Domains (1) summary
      cl40708
      Location:18 → 293
      MviM; Predicted dehydrogenase [General function prediction only]

    4. NM_001368389.1 → NP_001355318.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC152826
      Conserved Domains (1) summary
      cl40708
      Location:18 → 293
      MviM; Predicted dehydrogenase [General function prediction only]

    5. NM_027469.5 → NP_081745.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_081745.1

      Status: VALIDATED

      Source sequence(s)
      AC152826
      Consensus CDS
      CCDS22612.1
      UniProtKB/Swiss-Prot
      Q9CYH5
      Related
      ENSMUSP00000013294.10, ENSMUST00000013294.16
      Conserved Domains (1) summary
      COG0673
      Location:7 → 364
      MviM; Predicted dehydrogenase [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106440676..106485299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243753.2 → XP_030099613.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      cl40708
      Location:20 → 264
      MviM; Predicted dehydrogenase [General function prediction only]

    2. XM_036154282.1 → XP_036010175.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      cl40708
      Location:20 → 264
      MviM; Predicted dehydrogenase [General function prediction only]

    3. XM_011248499.4 → XP_011246801.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011246801.1

      Conserved Domains (1) summary
      COG0673
      Location:7 → 404
      MviM; Predicted dehydrogenase [General function prediction only]

    4. XM_036154281.1 → XP_036010174.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cl40708
      Location:18 → 293
      MviM; Predicted dehydrogenase [General function prediction only]

    5. XM_006531348.5 → XP_006531411.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006531411.1

      Conserved Domains (1) summary
      COG0673
      Location:7 → 404
      MviM; Predicted dehydrogenase [General function prediction only]

    6. XM_017312958.3 → XP_017168447.1  glucose-fructose oxidoreductase domain-containing protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q9CYH5
      Conserved Domains (1) summary
      COG0673
      Location:7 → 364
      MviM; Predicted dehydrogenase [General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYH5.1 GenPept UniProtKB/Swiss-Prot:Q9CYH5

    Gene LinkOut

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