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    Zbtb44 zinc finger and BTB domain containing 44 [ Mus musculus (house mouse) ]

    Gene ID: 235132, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zbtb44provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 44provided by MGI
    Primary source
    MGI:MGI:1925123
    See related
    Ensembl:ENSMUSG00000047412 AllianceGenome:MGI:1925123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Btbd15; E230011F09; 6030404E16Rik
    Summary
    Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZBTB44 (zinc finger and BTB domain containing 44). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 5.6), adrenal adult (RPKM 3.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb44 in Genome Data Viewer
    Location:
    9 A4; 9 16.56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (30941016..30987181)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31029720..31075885)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 8 Neighboring gene predicted gene, 29724 Neighboring gene STARR-seq mESC enhancer starr_23676 Neighboring gene STARR-seq mESC enhancer starr_23679 Neighboring gene STARR-positive B cell enhancer ABC_E6719 Neighboring gene STARR-seq mESC enhancer starr_23682 Neighboring gene STARR-seq mESC enhancer starr_23684 Neighboring gene predicted gene, 17508 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene suppression of tumorigenicity 14 (colon carcinoma) Neighboring gene STARR-seq mESC enhancer starr_23691 Neighboring gene amyloid beta precursor-like protein 2 Neighboring gene protein CEBPZOS pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
    3. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 44
    Names
    BTB (POZ) domain containing 15
    BTB/POZ domain-containing protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115130.1 → NP_001108602.1  zinc finger and BTB domain-containing protein 44 isoform a

      See identical proteins and their annotated locations for NP_001108602.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK036895, BC027138, BC090965, CT025653
      Consensus CDS
      CCDS52747.1
      UniProtKB/Swiss-Prot
      Q8CB31, Q8R0A2
      Related
      ENSMUSP00000110877.3, ENSMUST00000115222.10
      Conserved Domains (6) summary
      smart00225
      Location:32 → 128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:383 → 449
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:401 → 421
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:399 → 421
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:21 → 125
      BTB; BTB/POZ domain
      pfam13465
      Location:413 → 438
      zf-H2C2_2; Zinc-finger double domain

    2. NM_172765.3 → NP_766353.2  zinc finger and BTB domain-containing protein 44 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) uses an alternate in-frame splice site in the 3' coding region, compared to variant a. It encodes a shorter isoform (b), compared to isoform a.
      Source sequence(s)
      AK036895, BC027138, BC090965, CT025653
      Consensus CDS
      CCDS40568.1
      UniProtKB/Swiss-Prot
      Q8R0A2
      Related
      ENSMUSP00000149386.2, ENSMUST00000216649.2
      Conserved Domains (6) summary
      smart00225
      Location:32 → 128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:351 → 431
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:381 → 403
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:21 → 125
      BTB; BTB/POZ domain
      pfam13465
      Location:395 → 420
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      30941016..30987181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510215.5 → XP_006510278.1  zinc finger and BTB domain-containing protein 44 isoform X1

      UniProtKB/TrEMBL
      A0A1L1SQN1, A0A1L1SSL7
      Related
      ENSMUSP00000149969.2, ENSMUST00000217092.2
      Conserved Domains (5) summary
      sd00017
      Location:401 → 421
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:489 → 511
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:399 → 421
      zf-C2H2; Zinc finger, C2H2 type
      cd18228
      Location:15 → 130
      BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
      pfam13465
      Location:413 → 438
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006510216.5 → XP_006510279.1  zinc finger and BTB domain-containing protein 44 isoform X2

      UniProtKB/TrEMBL
      A0A1L1SQN1
      Conserved Domains (4) summary
      COG5048
      Location:351 → 432
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:472 → 494
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18228
      Location:15 → 130
      BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)

    3. XM_036154869.1 → XP_036010762.1  zinc finger and BTB domain-containing protein 44 isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:351 → 432
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:384 → 404
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18228
      Location:15 → 130
      BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)

    4. XM_006510217.5 → XP_006510280.1  zinc finger and BTB domain-containing protein 44 isoform X3

      UniProtKB/TrEMBL
      A0A1L1SQN1
      Related
      ENSMUSP00000149121.2, ENSMUST00000214585.2
      Conserved Domains (5) summary
      COG5048
      Location:351 → 431
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:383 → 403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:471 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18228
      Location:15 → 130
      BTB_POZ_ZBTB44; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44)
      pfam13465
      Location:395 → 420
      zf-H2C2_2; Zinc-finger double domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177768.2: Suppressed sequence

      Description
      NM_177768.2: This RefSeq was permanently suppressed because it is primarily UTR sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0A2.2 GenPept UniProtKB/Swiss-Prot:Q8R0A2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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