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    Tspan14 tetraspanin 14 [ Mus musculus (house mouse) ]

    Gene ID: 52588, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tspan14provided by MGI
    Official Full Name
    tetraspanin 14provided by MGI
    Primary source
    MGI:MGI:1196325
    See related
    Ensembl:ENSMUSG00000037824 AllianceGenome:MGI:1196325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tm4sf14; tspan-14; D14Ertd226e
    Summary
    Enables enzyme binding activity. Involved in protein maturation. Located in cell surface and tetraspanin-enriched microdomain. Is expressed in several structures, including central nervous system; retina; and salivary gland. Orthologous to human TSPAN14 (tetraspanin 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 50.8), kidney adult (RPKM 41.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspan14 in Genome Data Viewer
    Location:
    14 B; 14 22.36 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (40628384..40688835, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (40906427..40967073, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_36460 Neighboring gene STARR-seq mESC enhancer starr_36461 Neighboring gene STARR-seq mESC enhancer starr_36462 Neighboring gene SH2 domain containing 4B Neighboring gene STARR-seq mESC enhancer starr_36464 Neighboring gene STARR-seq mESC enhancer starr_36467 Neighboring gene STARR-seq mESC enhancer starr_36469 Neighboring gene STARR-positive B cell enhancer ABC_E9893 Neighboring gene VISTA enhancer mm1503 Neighboring gene STARR-positive B cell enhancer ABC_E4105 Neighboring gene STARR-positive B cell enhancer ABC_E8554 Neighboring gene STARR-positive B cell enhancer ABC_E5429 Neighboring gene predicted gene, 31839 Neighboring gene peroxiredoxin like 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
    2. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
    3. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
    4. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    5. ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease. Cozzolino F, et al. Hum Mol Genet, 2021 Jun 17. PMID 33601422

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC36554

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in tetraspanin-enriched microdomain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tetraspanin-14
    Names
    transmembrane 4 superfamily member 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316748.1 → NP_001303677.1  tetraspanin-14

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC108430, AK030593, BG807867
      Consensus CDS
      CCDS26956.1
      UniProtKB/Swiss-Prot
      Q8QZY6
      Related
      ENSMUSP00000153208.2, ENSMUST00000224209.2
      Conserved Domains (1) summary
      cd03159
      Location:113 → 233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    2. NM_145928.3 → NP_666040.1  tetraspanin-14

      See identical proteins and their annotated locations for NP_666040.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC154597, CT025537
      Consensus CDS
      CCDS26956.1
      UniProtKB/Swiss-Prot
      Q8QZY6
      Related
      ENSMUSP00000035263.6, ENSMUST00000047652.6
      Conserved Domains (1) summary
      cd03159
      Location:113 → 233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    RNA

    1. NR_188877.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108430, AC154597, CT025537

    2. NR_188878.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BY232291, CT025537

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      40628384..40688835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158755.1 → XP_036014648.1  tetraspanin-14 isoform X1

      UniProtKB/Swiss-Prot
      Q8QZY6
      Conserved Domains (1) summary
      cd03159
      Location:113 → 233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    2. XM_006519261.2 → XP_006519324.1  tetraspanin-14 isoform X1

      See identical proteins and their annotated locations for XP_006519324.1

      UniProtKB/Swiss-Prot
      Q8QZY6
      Conserved Domains (1) summary
      cd03159
      Location:113 → 233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...

    3. XM_036158753.1 → XP_036014646.1  tetraspanin-14 isoform X1

      UniProtKB/Swiss-Prot
      Q8QZY6
      Conserved Domains (1) summary
      cd03159
      Location:113 → 233
      TM4SF9_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8QZY6.1 GenPept UniProtKB/Swiss-Prot:Q8QZY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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