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    Haus4 HAUS augmin-like complex, subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 219072, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Haus4provided by MGI
    Official Full Name
    HAUS augmin-like complex, subunit 4provided by MGI
    Primary source
    MGI:MGI:1261794
    See related
    Ensembl:ENSMUSG00000022177 AllianceGenome:MGI:1261794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D14Ertd500e; 9430093H08Rik
    Summary
    Predicted to enable microtubule minus-end binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centrosome and mitotic spindle microtubule. Predicted to be part of HAUS complex. Is expressed in cartilage; musculoskeletal system; and sensory organ. Orthologous to human HAUS4 (HAUS augmin like complex subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 20.6), genital fat pad adult (RPKM 10.1) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Haus4 in Genome Data Viewer
    Location:
    14 C2; 14 27.83 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54779242..54792446, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54541785..54554989, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA arginine 6 (anticodon ACG) Neighboring gene predicted gene, 53858 Neighboring gene STARR-seq mESC enhancer starr_36740 Neighboring gene ajuba LIM protein Neighboring gene STARR-seq mESC enhancer starr_36741 Neighboring gene STARR-positive B cell enhancer ABC_E7313 Neighboring gene U6 small nuclear RNA, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
    3. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centrosome cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of HAUS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of HAUS complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    HAUS augmin-like complex subunit 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145462.2 → NP_663437.2  HAUS augmin-like complex subunit 4

      See identical proteins and their annotated locations for NP_663437.2

      Status: VALIDATED

      Source sequence(s)
      AI642699, AK079852, BB855694
      Consensus CDS
      CCDS27092.1
      UniProtKB/Swiss-Prot
      Q8BFT2, Q99KI1
      Related
      ENSMUSP00000022784.9, ENSMUST00000022784.9
      Conserved Domains (1) summary
      pfam14735
      Location:126 → 360
      HAUS4; HAUS augmin-like complex subunit 4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      54779242..54792446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247756.1 → XP_030103616.1  HAUS augmin-like complex subunit 4 isoform X2

      Conserved Domains (1) summary
      pfam14735
      Location:1 → 210
      HAUS4; HAUS augmin-like complex subunit 4

    2. XM_006518845.5 → XP_006518908.1  HAUS augmin-like complex subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006518908.1

      UniProtKB/Swiss-Prot
      Q8BFT2, Q99KI1
      Conserved Domains (1) summary
      pfam14735
      Location:126 → 360
      HAUS4; HAUS augmin-like complex subunit 4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFT2.1 GenPept UniProtKB/Swiss-Prot:Q8BFT2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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