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    Nedd8 neural precursor cell expressed, developmentally down-regulated gene 8 [ Mus musculus (house mouse) ]

    Gene ID: 18002, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nedd8provided by MGI
    Official Full Name
    neural precursor cell expressed, developmentally down-regulated gene 8provided by MGI
    Primary source
    MGI:MGI:97301
    See related
    Ensembl:ENSMUSG00000010376 AllianceGenome:MGI:97301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rub1; NEDD-8
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Involved in regulation of postsynapse assembly. Acts upstream of or within protein localization and regulation of transcription by RNA polymerase II. Located in nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Orthologous to human NEDD8 (NEDD8 ubiquitin like modifier). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 174.5), CNS E14 (RPKM 168.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nedd8 in Genome Data Viewer
    Location:
    14 C3; 14 28.19 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55899720..55909337, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55662263..55671880, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene transmembrane 9 superfamily member 1 Neighboring gene testis-specific serine kinase 4 Neighboring gene magnesium-dependent phosphatase 1 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene Terf1 (TRF1)-interacting nuclear factor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56300752-56300861 Neighboring gene predicted gene, 25887

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein neddylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    NOT involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of postsynapse assembly EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    NEDD8
    Names
    neddylin
    neural precursor cell expressed developmentally down-regulated protein 8
    ubiquitin-like protein Nedd8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008683.4NP_032709.1  NEDD8

      See identical proteins and their annotated locations for NP_032709.1

      Status: VALIDATED

      Source sequence(s)
      AI847056, AK146732
      Consensus CDS
      CCDS49498.1
      UniProtKB/Swiss-Prot
      P29595
      UniProtKB/TrEMBL
      Q3TY05, Q3UI46
      Related
      ENSMUSP00000010520.9, ENSMUST00000010520.10
      Conserved Domains (1) summary
      cd01806
      Location:376
      Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55899720..55909337 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)