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    Rmi2 RecQ mediated genome instability 2 [ Mus musculus (house mouse) ]

    Gene ID: 223970, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rmi2provided by MGI
    Official Full Name
    RecQ mediated genome instability 2provided by MGI
    Primary source
    MGI:MGI:2685383
    See related
    Ensembl:ENSMUSG00000037991 AllianceGenome:MGI:2685383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm537; Gm929; A630055G03Rik
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and regulation of sister chromatid segregation. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in cytosol and nuclear speck. Is expressed in axial skeleton; bladder; embryo; and rib. Orthologous to human RMI2 (RecQ mediated genome instability 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thymus adult (RPKM 9.9), CNS E11.5 (RPKM 2.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rmi2 in Genome Data Viewer
    Location:
    16 A1; 16 6.06 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10652923..10661099)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10835059..10843235)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40096 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10806282-10806483 Neighboring gene protamine 1 Neighboring gene 60S ribosomal protein L30-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10814996-10815179 Neighboring gene STARR-positive B cell enhancer ABC_E8907 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10836584-10836853 Neighboring gene cyclin Y-like 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:10844126-10844349 Neighboring gene predicted gene, 53936 Neighboring gene predicted gene, 21859

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genome instability and embryonic developmental defects in RMI1 deficient mice. Guiraldelli MF, et al. DNA Repair (Amst), 2013 Oct. PMID 23900276, Free PMC Article
    2. Role of replication protein A in double holliday junction dissolution mediated by the BLM-Topo IIIα-RMI1-RMI2 protein complex. Xue X, et al. J Biol Chem, 2013 May 17. PMID 23543748, Free PMC Article
    3. Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3. Villegas F, et al. Cell Stem Cell, 2019 Feb 7. PMID 30595499
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of rDNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sister chromatid segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in resolution of DNA recombination intermediates ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RecQ family helicase-topoisomerase III complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    recQ-mediated genome instability protein 2
    Names
    RMI2, RecQ mediated genome instability 2, homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162932.1 → NP_001156404.1  recQ-mediated genome instability protein 2

      See identical proteins and their annotated locations for NP_001156404.1

      Status: VALIDATED

      Source sequence(s)
      CT010583
      Consensus CDS
      CCDS49761.1
      UniProtKB/Swiss-Prot
      Q3UPE3, Q3V2Y5
      Related
      ENSMUSP00000042676.8, ENSMUST00000037913.9
      Conserved Domains (1) summary
      pfam16100
      Location:24 → 143
      RMI2; RecQ-mediated genome instability protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      10652923..10661099
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033278.1: Suppressed sequence

      Description
      NM_001033278.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UPE3.1 GenPept UniProtKB/Swiss-Prot:Q3UPE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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