Pros1 protein S (alpha) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pros1provided by MGI
Official Full Name: protein S (alpha)provided by MGI
Primary source: MGI:MGI:1095733
See related: Ensembl:ENSMUSG00000022912 AllianceGenome:MGI:1095733
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a vitamin K-dependent protein with key roles in multiple biological processes including coagulation, apoptosis and vasculogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein which is secreted into the plasma. Mice lacking the encoded protein die in utero from a fulminant coagulopathy and associated hemorrhages. [provided by RefSeq, Oct 2015]
Expression: Ubiquitous expression in placenta adult (RPKM 16.0), bladder adult (RPKM 11.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C1.3; 16 36.43 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (62674670..62749709)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (62854307..62929346)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutaredoxin 1 regulates cholesterol metabolism and gallstone formation by influencing protein S-glutathionylation.
Title: Glutaredoxin 1 regulates cholesterol metabolism and gallstone formation by influencing protein S-glutathionylation.
Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1alpha S-glutathionylation during posterior capsular opacification.
Title: Glutaredoxin 1 protects lens epithelial cells from epithelial-mesenchymal transition by preventing casein kinase 1α S-glutathionylation during posterior capsular opacification.
Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration.
Title: Endothelial HDAC1-ZEB2-NuRD Complex Drives Aortic Aneurysm and Dissection Through Regulation of Protein S-Sulfhydration.
Myeloid cell-derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10.
Title: Myeloid cell-derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10.
The tumor-derived Pros1 immune suppressive system, like PD-L1, was cytokine responsive, with IFN-gamma inducing Pros1 transcription and secretion. Inhibition of Pros1/TAM interaction represents a potential novel strategy to block tumor-derived immune suppression.
Title: Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response.
Our results support a protective role of PS against glomerular injury in DN progression.
Title: Protein S Protects against Podocyte Injury in Diabetic Nephropathy.
Mertk(-/-) mice showed exacerbated arthritis pathology, whereas Pros1 overexpression diminished joint pathology.
Title: Protective Role of the MER Tyrosine Kinase via Efferocytosis in Rheumatoid Arthritis Models.
MerTK ligands Gas6 and Protein S are expressed in both RPE cells and photoreceptors, and at least one of them is required for phagocytosis to occur. With opposite effects on RPE phagocytosis and changes in their expression levels around the time of POS uptake, Gas6 and Protein S may contribute to the tight control of the acute phagocytic peak in the retina. Review.
Title: Opposite Roles of MerTK Ligands Gas6 and Protein S During Retinal Phagocytosis.
macrophage-derived PROS1 is an important effector molecule in regulating the efferocytosis, maturation, and reprogramming of resolution phase macrophages
Title: Macrophage-Derived Protein S Facilitates Apoptotic Polymorphonuclear Cell Clearance by Resolution Phase Macrophages and Supports Their Reprogramming.
These results establish PS inhibition as both controller of coagulation and potential therapeutic target in hemophilia. The murine PS silencing RNA approach that we successfully used in hemophilic mice might constitute a new therapeutic concept for hemophilic patients.
Title: Targeting anticoagulant protein S to improve hemostasis in hemophilia.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

General gene information

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Markers

L27439 (e-PCR)
- UniSTS:160580

Pros1 (e-PCR), detects polymorphism
- UniSTS:525937

AW214361 (e-PCR)
- UniSTS:180928

L27439 (e-PCR)
- UniSTS:124890

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in fibrinolysis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of coagulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vitamin K-dependent protein S

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011173.3 → NP_035303.1 vitamin K-dependent protein S preproprotein

See identical proteins and their annotated locations for NP_035303.1

Status: REVIEWED

Source sequence(s)

AK145501, AK163032, BE949628

Consensus CDS

CCDS28263.1

UniProtKB/Swiss-Prot

P43483, Q08761

UniProtKB/TrEMBL

Q3TR66

Related

ENSMUSP00000023629.9, ENSMUST00000023629.9

Conserved Domains (6) summary

smart00069
Location:23 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

pfam00054
Location:329 → 459

Laminin_G_1; Laminin G domain

pfam06247
Location:134 → 287

Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28

pfam07645
Location:201 → 241

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:165 → 199

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl22861
Location:514 → 646

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

62674670..62749709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245843.4 → XP_011244145.1 vitamin K-dependent protein S isoform X1

Conserved Domains (5) summary

pfam07645
Location:121 → 161

EGF_CA; Calcium-binding EGF domain

pfam00008
Location:41 → 73

EGF; EGF-like domain

pfam00054
Location:249 → 379

Laminin_G_1; Laminin G domain

pfam14670
Location:85 → 119

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl22861
Location:429 → 566

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...