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    St6gal2 beta galactoside alpha 2,6 sialyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 240119, updated on 27-Nov-2024

    Summary

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    Official Symbol
    St6gal2provided by MGI
    Official Full Name
    beta galactoside alpha 2,6 sialyltransferase 2provided by MGI
    Primary source
    MGI:MGI:2445190
    See related
    Ensembl:ENSMUSG00000024172 AllianceGenome:MGI:2445190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    St6galII; mKIAA1877; C230064G14Rik
    Summary
    Enables sialyltransferase activity. Predicted to be involved in oligosaccharide metabolic process and sialylation. Predicted to act upstream of or within N-acetylneuraminate metabolic process. Predicted to be located in Golgi cisterna membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including central nervous system; genitourinary system; lung; skeletal muscle; and spleen. Orthologous to human ST6GAL2 (ST6 beta-galactoside alpha-2,6-sialyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 9.2), whole brain E14.5 (RPKM 5.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See St6gal2 in Genome Data Viewer
    Location:
    17 C; 17 28.82 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (55752071..55821582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (55445118..55514581)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42865 Neighboring gene nuclear transport factor 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42866 Neighboring gene STARR-seq mESC enhancer starr_42867 Neighboring gene predicted gene 4471 Neighboring gene STARR-seq mESC enhancer starr_42868 Neighboring gene vomeronasal 2, receptor 118 Neighboring gene predicted gene, 22654 Neighboring gene protection of telomeres 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes. Ohmi Y, et al. Glycobiology, 2021 Jun 3. PMID 33242079
    2. Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II. Krzewinski-Recchi MA, et al. Eur J Biochem, 2003 Mar. PMID 12603328
    3. Comparison of the enzymatic properties of mouse beta-galactoside alpha2,6-sialyltransferases, ST6Gal I and II. Takashima S, et al. J Biochem, 2003 Aug. PMID 12966079
    4. Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Alderman PJ, et al. Neuron, 2024 Feb 21. PMID 38086370,
    5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
      Title: Majority of alpha2,6-sialylated glycans in the adult mouse brain exist in O-glycans: SALSA-MS analysis for knockout mice of alpha2,6-sialyltransferase genes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-galactoside alpha-2,6-sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-galactoside alpha-2,6-sialyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables beta-galactoside alpha-2,6-sialyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-acetylneuraminate metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in oligosaccharide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sialylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    beta-galactoside alpha-2,6-sialyltransferase 2
    Names
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2
    beta-galactoside alpha-2,6-sialyltransferase II
    NP_001334332.1
    XP_006524330.1
    XP_006524331.1
    XP_006524332.1
    XP_030105661.1
    XP_030105662.1
    XP_036016499.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347403.1 → NP_001334332.1  beta-galactoside alpha-2,6-sialyltransferase 2

      Status: VALIDATED

      Source sequence(s)
      BE991433, CT009635
      Consensus CDS
      CCDS84324.1
      UniProtKB/Swiss-Prot
      A9C434, Q6ZPG5, Q76K27, Q8BUU4
      UniProtKB/TrEMBL
      B2RQY9
      Related
      ENSMUSP00000025000.4, ENSMUST00000025000.4
      Conserved Domains (1) summary
      pfam00777
      Location:276 → 506
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      55752071..55821582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524267.4 → XP_006524330.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006524330.1

      UniProtKB/Swiss-Prot
      A9C434, Q6ZPG5, Q76K27, Q8BUU4
      UniProtKB/TrEMBL
      B2RQY9
      Conserved Domains (1) summary
      pfam00777
      Location:276 → 506
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. XM_030249801.2 → XP_030105661.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      A9C434, Q6ZPG5, Q76K27, Q8BUU4
      UniProtKB/TrEMBL
      B2RQY9
      Conserved Domains (1) summary
      pfam00777
      Location:276 → 506
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. XM_006524268.4 → XP_006524331.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006524331.1

      UniProtKB/Swiss-Prot
      A9C434, Q6ZPG5, Q76K27, Q8BUU4
      UniProtKB/TrEMBL
      B2RQY9
      Conserved Domains (1) summary
      pfam00777
      Location:276 → 506
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. XM_030249802.2 → XP_030105662.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      A9C434, Q6ZPG5, Q76K27, Q8BUU4
      UniProtKB/TrEMBL
      B2RQY9
      Conserved Domains (1) summary
      pfam00777
      Location:276 → 506
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. XM_006524269.3 → XP_006524332.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006524332.1

      UniProtKB/Swiss-Prot
      A9C434, Q6ZPG5, Q76K27, Q8BUU4
      UniProtKB/TrEMBL
      B2RQY9
      Conserved Domains (1) summary
      pfam00777
      Location:276 → 506
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. XM_036160606.1 → XP_036016499.1  beta-galactoside alpha-2,6-sialyltransferase 2 isoform X1

      UniProtKB/Swiss-Prot
      A9C434, Q6ZPG5, Q76K27, Q8BUU4
      UniProtKB/TrEMBL
      B2RQY9
      Conserved Domains (1) summary
      pfam00777
      Location:276 → 506
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RNA

    1. XR_004939531.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172829.2: Suppressed sequence

      Description
      NM_172829.2: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q76K27.2 GenPept UniProtKB/Swiss-Prot:Q76K27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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