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    Mlst8 MTOR associated protein, LST8 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 56716, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mlst8provided by MGI
    Official Full Name
    MTOR associated protein, LST8 homolog (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:1929514
    See related
    Ensembl:ENSMUSG00000024142 AllianceGenome:MGI:1929514
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gbl; 0610033N12Rik
    Summary
    Predicted to enable protein serine/threonine kinase activator activity. Acts upstream of or within positive regulation of actin filament polymerization and positive regulation of peptidyl-tyrosine phosphorylation. Part of TORC1 complex. Is expressed in central nervous system and retina. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.9), large intestine adult (RPKM 14.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mlst8 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.39 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24692524..24698722, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24473550..24479114, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4833447I15 gene Neighboring gene STARR-positive B cell enhancer ABC_E7497 Neighboring gene STARR-positive B cell enhancer ABC_E5578 Neighboring gene phosphoglycolate phosphatase Neighboring gene BRICHOS domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_42087 Neighboring gene CASK interacting protein 1 Neighboring gene TNF receptor-associated factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E33 Neighboring gene RAB26, member RAS oncogene family, opposite strand Neighboring gene small nucleolar RNA, C/D box 60

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein serine/threonine kinase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TORC2 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hypoxia NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to nutrient levels NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to osmotic stress NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of autophagy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of glycolytic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of lipid biosynthetic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of pentose-phosphate shunt NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TORC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TORC1 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TORC2 complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    part_of TORC2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    target of rapamycin complex subunit LST8
    Names
    TORC subunit LST8
    mammalian lethal with SEC13 protein 8
    protein GbetaL
    transducin (beta)-like 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252463.1NP_001239392.1  target of rapamycin complex subunit LST8 isoform 1

      See identical proteins and their annotated locations for NP_001239392.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the longer isoform (1).
      Source sequence(s)
      AC154237, AK002751, AK040100
      Consensus CDS
      CCDS28484.1
      UniProtKB/Swiss-Prot
      Q8BNG8, Q8C882, Q9DCJ1, Q9JKK6
      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Related
      ENSMUSP00000157301.2, ENSMUST00000234335.2
      Conserved Domains (3) summary
      COG2319
      Location:10305
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:14297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4783
      7WD40; WD40 repeat [structural motif]
    2. NM_001252464.1NP_001239393.1  target of rapamycin complex subunit LST8 isoform 1

      See identical proteins and their annotated locations for NP_001239393.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the longer isoform (1).
      Source sequence(s)
      AC154237, AK040100, AK083731, CF750475
      Consensus CDS
      CCDS28484.1
      UniProtKB/Swiss-Prot
      Q8BNG8, Q8C882, Q9DCJ1, Q9JKK6
      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Related
      ENSMUSP00000136287.2, ENSMUST00000179163.3
      Conserved Domains (3) summary
      COG2319
      Location:10305
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:14297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4783
      7WD40; WD40 repeat [structural motif]
    3. NM_001252465.1NP_001239394.1  target of rapamycin complex subunit LST8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two internal exons and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC154237, AK040100, BM947104
      Consensus CDS
      CCDS89006.1
      UniProtKB/TrEMBL
      A0A3Q4EC26, A0A3Q4L2V5
      Related
      ENSMUSP00000157225.2, ENSMUST00000234543.2
      Conserved Domains (3) summary
      COG2319
      Location:1257
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:2361
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:5231
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_019988.5NP_064372.2  target of rapamycin complex subunit LST8 isoform 1

      See identical proteins and their annotated locations for NP_064372.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the longer isoform (1).
      Source sequence(s)
      AC154237, AK040100
      Consensus CDS
      CCDS28484.1
      UniProtKB/Swiss-Prot
      Q8BNG8, Q8C882, Q9DCJ1, Q9JKK6
      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Related
      ENSMUSP00000065004.7, ENSMUST00000070888.14
      Conserved Domains (3) summary
      COG2319
      Location:10305
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:14297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4783
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24692524..24698722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317586.2XP_017173075.1  target of rapamycin complex subunit LST8 isoform X1

      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Conserved Domains (2) summary
      cd00200
      Location:14299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4783
      7WD40; WD40 repeat [structural motif]
    2. XM_006524679.5XP_006524742.1  target of rapamycin complex subunit LST8 isoform X3

      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Conserved Domains (2) summary
      cd00200
      Location:14296
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4682
      7WD40; WD40 repeat [structural motif]
    3. XM_006524678.3XP_006524741.1  target of rapamycin complex subunit LST8 isoform X2

      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Conserved Domains (2) summary
      cd00200
      Location:14298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4682
      7WD40; WD40 repeat [structural motif]
    4. XM_030249921.1XP_030105781.1  target of rapamycin complex subunit LST8 isoform X2

      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Conserved Domains (2) summary
      cd00200
      Location:14298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4682
      7WD40; WD40 repeat [structural motif]
    5. XM_017317587.1XP_017173076.1  target of rapamycin complex subunit LST8 isoform X1

      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Conserved Domains (2) summary
      cd00200
      Location:14299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4783
      7WD40; WD40 repeat [structural motif]
    6. XM_030249920.2XP_030105780.1  target of rapamycin complex subunit LST8 isoform X1

      UniProtKB/TrEMBL
      A0A3Q4L2V5
      Conserved Domains (2) summary
      cd00200
      Location:14299
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:4783
      7WD40; WD40 repeat [structural motif]