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    Traf7 TNF receptor-associated factor 7 [ Mus musculus (house mouse) ]

    Gene ID: 224619, updated on 9-Dec-2024

    Summary

    Official Symbol
    Traf7provided by MGI
    Official Full Name
    TNF receptor-associated factor 7provided by MGI
    Primary source
    MGI:MGI:3042141
    See related
    Ensembl:ENSMUSG00000052752 AllianceGenome:MGI:3042141
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RFWD1
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including cellular response to interleukin-6; negative regulation of transcription by RNA polymerase II; and positive regulation of protein sumoylation. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in genitourinary system and pancreas epithelium. Human ortholog(s) of this gene implicated in adenomatoid tumor; hepatocellular carcinoma; and peritoneal mesothelioma. Orthologous to human TRAF7 (TNF receptor associated factor 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 69.0), lung adult (RPKM 60.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Traf7 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.4 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24727824..24746912, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24508850..24527938, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phosphoglycolate phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E5578 Neighboring gene BRICHOS domain containing 5 Neighboring gene MTOR associated protein, LST8 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_42087 Neighboring gene CASK interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E33 Neighboring gene RAB26, member RAS oncogene family, opposite strand Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene RAB26, member RAS oncogene family

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC7807

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to interleukin-6 IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein sumoylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K29-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRAF7
    Names
    RING-type E3 ubiquitin transferase TRAF7
    ring finger and WD repeat domain 1
    NP_001165584.1
    NP_001165585.1
    NP_001402080.1
    NP_722487.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172113.2NP_001165584.1  E3 ubiquitin-protein ligase TRAF7 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC132367
      Consensus CDS
      CCDS50014.1
      UniProtKB/Swiss-Prot
      Q922B6, Q99JV3
      UniProtKB/TrEMBL
      F8WJF7
      Related
      ENSMUSP00000134759.2, ENSMUST00000176652.8
      Conserved Domains (6) summary
      cl17044
      Location:281321
      DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
      smart00184
      Location:130162
      RING; Ring finger
      COG2319
      Location:379667
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:387667
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:442476
      7WD40; WD40 repeat [structural motif]
      cl19105
      Location:206279
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    2. NM_001172114.2NP_001165585.1  E3 ubiquitin-protein ligase TRAF7 isoform 2

      See identical proteins and their annotated locations for NP_001165585.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AC132367
      Consensus CDS
      CCDS50015.1
      UniProtKB/Swiss-Prot
      Q922B6, Q99JV3
      UniProtKB/TrEMBL
      Q8C2K8
      Related
      ENSMUSP00000135267.2, ENSMUST00000176353.8
      Conserved Domains (6) summary
      cl17044
      Location:241281
      DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
      smart00184
      Location:92124
      RING; Ring finger
      COG2319
      Location:339627
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:347627
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:402436
      7WD40; WD40 repeat [structural motif]
      cl19105
      Location:168239
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
    3. NM_001415151.1NP_001402080.1  E3 ubiquitin-protein ligase TRAF7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132367
      UniProtKB/Swiss-Prot
      Q922B6, Q99JV3
    4. NM_153792.2NP_722487.2  E3 ubiquitin-protein ligase TRAF7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and a downstream start codon, compared to variant 1. Isoform 3 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC132367
      UniProtKB/Swiss-Prot
      Q922B6, Q99JV3
      Conserved Domains (6) summary
      cl17044
      Location:254294
      DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
      smart00184
      Location:103135
      RING; Ring finger
      COG2319
      Location:352640
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:360640
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:415449
      7WD40; WD40 repeat [structural motif]
      cl19105
      Location:179252
      Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24727824..24746912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)