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    Tsc2 TSC complex subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 22084, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tsc2provided by MGI
    Official Full Name
    TSC complex subunit 2provided by MGI
    Primary source
    MGI:MGI:102548
    See related
    Ensembl:ENSMUSG00000002496 AllianceGenome:MGI:102548
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcs2; Nafld
    Summary
    Enables 14-3-3 protein binding activity and GTPase activator activity. Involved in several processes, including anoikis; chemical synaptic transmission; and negative regulation of TORC1 signaling. Acts upstream of or within several processes, including intracellular protein transport; negative regulation of lymphocyte proliferation; and regulation of signal transduction. Located in cytoplasm. Part of TSC1-TSC2 complex. Is active in lysosomal membrane and synapse. Is expressed in several structures, including aorta; central nervous system; genitourinary system; hemolymphoid system gland; and retina. Used to study autism spectrum disorder; tuberous sclerosis; and uterine fibroid. Human ortholog(s) of this gene implicated in hepatic angiomyolipoma; lymphangioleiomyomatosis; medulloblastoma; tuberous sclerosis; and tuberous sclerosis 2. Orthologous to human TSC2 (TSC complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 31.9), ovary adult (RPKM 27.3) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tsc2 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.41 cM
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24814788..24851607, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24595816..24632676, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33508 Neighboring gene STARR-positive B cell enhancer ABC_E1189 Neighboring gene predicted gene, 57643 Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene STARR-seq mESC enhancer starr_42089 Neighboring gene STARR-positive B cell enhancer ABC_E7498 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:24769632-24769741 Neighboring gene nth (endonuclease III)-like 1 (E.coli) Neighboring gene NHERF family PDZ scaffold protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp90 protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within D-glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of T cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in anoikis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anoikis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anoikis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to starvation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in excitatory chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in inhibitory chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of T cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of pinocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein transport into plasma membrane raft IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of TSC1-TSC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of TSC1-TSC2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of TSC1-TSC2 complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of TSC1-TSC2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in caveola ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tuberin
    Names
    tuberous sclerosis 2 protein homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039363.3NP_001034452.1  tuberin isoform 2

      See identical proteins and their annotated locations for NP_001034452.1

      Status: VALIDATED

      Source sequence(s)
      AC132367
      Consensus CDS
      CCDS28486.1
      UniProtKB/TrEMBL
      Q3TCQ7, Q7TT21
      Related
      ENSMUSP00000094986.2, ENSMUST00000097373.2
      Conserved Domains (3) summary
      pfam02145
      Location:14981684
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin
      pfam11864
      Location:54419
      DUF3384; Domain of unknown function (DUF3384)
    2. NM_001286713.2NP_001273642.1  tuberin isoform 3

      See identical proteins and their annotated locations for NP_001273642.1

      Status: VALIDATED

      Source sequence(s)
      AC132367
      Consensus CDS
      CCDS89010.1
      UniProtKB/TrEMBL
      Q3UG88, Q3UHB2
      Related
      ENSMUSP00000154338.2, ENSMUST00000227745.2
      Conserved Domains (3) summary
      pfam02145
      Location:15641750
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin
      pfam11864
      Location:54469
      DUF3384; Domain of unknown function (DUF3384)
    3. NM_001286714.2NP_001273643.1  tuberin isoform 1

      See identical proteins and their annotated locations for NP_001273643.1

      Status: VALIDATED

      Source sequence(s)
      AC132367
      Consensus CDS
      CCDS89009.1
      UniProtKB/TrEMBL
      A0A2I3BPP1, Q3UG88
      Conserved Domains (3) summary
      pfam02145
      Location:15411727
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin; Tuberin
      pfam11864
      Location:54466
      DUF3384; Domain of unknown function (DUF3384)
    4. NM_001286716.2NP_001273645.1  tuberin isoform 2

      See identical proteins and their annotated locations for NP_001273645.1

      Status: VALIDATED

      Source sequence(s)
      AC132367
      Consensus CDS
      CCDS28486.1
      UniProtKB/TrEMBL
      Q3TCQ7, Q7TT21
      Related
      ENSMUSP00000153792.2, ENSMUST00000226398.2
      Conserved Domains (3) summary
      pfam02145
      Location:14981684
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin
      pfam11864
      Location:54419
      DUF3384; Domain of unknown function (DUF3384)
    5. NM_001286718.2NP_001273647.1  tuberin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132367
      Consensus CDS
      CCDS89008.1
      UniProtKB/TrEMBL
      A0A2I3BRT5, Q3TCQ7
      Related
      ENSMUSP00000154706.2, ENSMUST00000228412.2
      Conserved Domains (3) summary
      pfam02145
      Location:14971683
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin; Tuberin
      pfam11864
      Location:54466
      DUF3384; Domain of unknown function (DUF3384)
    6. NM_001286720.2NP_001273649.1  tuberin isoform 5

      See identical proteins and their annotated locations for NP_001273649.1

      Status: VALIDATED

      Source sequence(s)
      AC132367
      UniProtKB/Swiss-Prot
      P97723, P97724, P97725, P97727, Q61007, Q61008, Q61037, Q9WUF6
      Conserved Domains (3) summary
      pfam02145
      Location:15641756
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin; Tuberin
      pfam11864
      Location:54466
      DUF3384; Domain of unknown function (DUF3384)
    7. NM_001403402.1NP_001390331.1  tuberin isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC132367
    8. NM_001403403.1NP_001390332.1  tuberin isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC132367
    9. NM_001403404.1NP_001390333.1  tuberin isoform 17

      Status: VALIDATED

      Source sequence(s)
      AC132367
    10. NM_001403405.1NP_001390334.1  tuberin isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC132367
    11. NM_001403406.1NP_001390335.1  tuberin isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC132367
    12. NM_001403407.1NP_001390336.1  tuberin isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC132367
    13. NM_001403408.1NP_001390337.1  tuberin isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC132367
    14. NM_001403409.1NP_001390338.1  tuberin isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC132367
    15. NM_001403410.1NP_001390339.1  tuberin isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC132367
    16. NM_001403411.1NP_001390340.1  tuberin isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC132367
    17. NM_001403412.1NP_001390341.1  tuberin isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC132367
    18. NM_001403413.1NP_001390342.1  tuberin isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC132367
    19. NM_001403414.1NP_001390343.1  tuberin isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC132367
    20. NM_001403415.1NP_001390344.1  tuberin isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC132367
    21. NM_001403416.1NP_001390345.1  tuberin isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC132367
    22. NM_001403417.1NP_001390346.1  tuberin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132367
    23. NM_001403418.1NP_001390347.1  tuberin isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC132367
    24. NM_011647.4NP_035777.2  tuberin isoform 1

      See identical proteins and their annotated locations for NP_035777.2

      Status: VALIDATED

      Source sequence(s)
      AC132367
      Consensus CDS
      CCDS89009.1
      UniProtKB/TrEMBL
      A0A2I3BPP1, Q3UG88
      Related
      ENSMUSP00000153869.2, ENSMUST00000226284.2
      Conserved Domains (3) summary
      pfam02145
      Location:15411727
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin; Tuberin
      pfam11864
      Location:54466
      DUF3384; Domain of unknown function (DUF3384)

    RNA

    1. NR_175374.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC132367

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24814788..24851607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317386.2XP_017172875.1  tuberin isoform X2

      UniProtKB/TrEMBL
      Q3UG88
      Conserved Domains (3) summary
      pfam02145
      Location:15631749
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:554902
      Tuberin
      pfam11864
      Location:54468
      DUF3384; Domain of unknown function (DUF3384)
    2. XM_017317384.3XP_017172873.1  tuberin isoform X19

      UniProtKB/TrEMBL
      Q3UG88, Q3UHB2
      Conserved Domains (3) summary
      pfam02145
      Location:15641750
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin
      pfam11864
      Location:54469
      DUF3384; Domain of unknown function (DUF3384)
    3. XM_017317393.2XP_017172882.1  tuberin isoform X16

      UniProtKB/TrEMBL
      Q3TCQ7
      Related
      ENSMUSP00000153758.2, ENSMUST00000227607.2
      Conserved Domains (3) summary
      pfam02145
      Location:14391625
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:496844
      Tuberin
      pfam11864
      Location:1410
      DUF3384; Domain of unknown function (DUF3384)
    4. XM_030249647.2XP_030105507.1  tuberin isoform X10

      UniProtKB/TrEMBL
      Q3UG88
      Conserved Domains (3) summary
      pfam02145
      Location:15051691
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:496844
      Tuberin
      pfam11864
      Location:1410
      DUF3384; Domain of unknown function (DUF3384)
    5. XM_036160475.1XP_036016368.1  tuberin isoform X3

      UniProtKB/TrEMBL
      Q3UG88
      Conserved Domains (3) summary
      pfam02145
      Location:15401726
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:555903
      Tuberin
      pfam11864
      Location:54419
      DUF3384; Domain of unknown function (DUF3384)
    6. XM_030249646.2XP_030105506.1  tuberin isoform X2

      UniProtKB/TrEMBL
      Q3UG88
      Conserved Domains (3) summary
      pfam02145
      Location:15631749
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:554902
      Tuberin
      pfam11864
      Location:54468
      DUF3384; Domain of unknown function (DUF3384)
    7. XM_017317390.2XP_017172879.1  tuberin isoform X10

      UniProtKB/TrEMBL
      Q3UG88
      Conserved Domains (3) summary
      pfam02145
      Location:15051691
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:496844
      Tuberin
      pfam11864
      Location:1410
      DUF3384; Domain of unknown function (DUF3384)
    8. XM_030249650.2XP_030105510.1  tuberin isoform X11

      UniProtKB/TrEMBL
      Q3UG88
      Conserved Domains (3) summary
      pfam02145
      Location:15041690
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:495843
      Tuberin
      pfam11864
      Location:1409
      DUF3384; Domain of unknown function (DUF3384)
    9. XM_030249648.1XP_030105508.1  tuberin isoform X10

      UniProtKB/TrEMBL
      Q3UG88
      Conserved Domains (3) summary
      pfam02145
      Location:15051691
      Rap_GAP; Rap/ran-GAP
      pfam03542
      Location:496844
      Tuberin
      pfam11864
      Location:1410
      DUF3384; Domain of unknown function (DUF3384)

    RNA

    1. XR_004939509.1 RNA Sequence

    2. XR_003952103.2 RNA Sequence