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    Npw neuropeptide W [ Mus musculus (house mouse) ]

    Gene ID: 381073, updated on 27-Nov-2024

    Summary

    Official Symbol
    Npwprovided by MGI
    Official Full Name
    neuropeptide Wprovided by MGI
    Primary source
    MGI:MGI:2685781
    See related
    Ensembl:ENSMUSG00000071230 AllianceGenome:MGI:2685781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm935
    Summary
    Orthologs of this gene express a preproprotein that is processed into a neuropeptide ligand for two G-protein coupled receptors in the central nervous system. The neuropeptide is thought to directly or indirectly regulate feeding, weight regulation, and pain response. The preproprotein is translated using a non-AUG initiation codon. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in stomach adult (RPKM 51.2) and lung adult (RPKM 38.0) See more
    Orthologs
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    Genomic context

    See Npw in Genome Data Viewer
    Location:
    17 A3.3; 17 12.45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24876303..24877526, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24657329..24658552, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:24769632-24769741 Neighboring gene nth (endonuclease III)-like 1 (E.coli) Neighboring gene NHERF family PDZ scaffold protein 2 Neighboring gene zinc finger protein 598 Neighboring gene STARR-positive B cell enhancer ABC_E11630 Neighboring gene synaptogyrin 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in feeding behavior IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099664.2NP_001093134.1  neuropeptide W preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC154566
      Consensus CDS
      CCDS50017.1
      UniProtKB/TrEMBL
      F7B5D6
      Related
      ENSMUSP00000093200.5, ENSMUST00000095544.6
      Conserved Domains (1) summary
      pfam15180
      Location:34140
      NPBW; Neuropeptides B and W

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24876303..24877526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)