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    Gfer growth factor, augmenter of liver regeneration [ Mus musculus (house mouse) ]

    Gene ID: 11692, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gferprovided by MGI
    Official Full Name
    growth factor, augmenter of liver regenerationprovided by MGI
    Primary source
    MGI:MGI:107757
    See related
    Ensembl:ENSMUSG00000040888 AllianceGenome:MGI:107757
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Alr; ERV1
    Summary
    Predicted to enable flavin adenine dinucleotide binding activity and flavin-dependent sulfhydryl oxidase activity. Predicted to be involved in several processes, including liver regeneration; negative regulation of natural killer cell mediated cytotoxicity; and positive regulation of DNA biosynthetic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in kidney failure and renal fibrosis. Orthologous to human GFER (growth factor, augmenter of liver regeneration). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 40.9), colon adult (RPKM 27.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Gfer in Genome Data Viewer
    Location:
    17 A3.3; 17 12.48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24912164..24915065, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24693190..24696156, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 598 Neighboring gene STARR-positive B cell enhancer ABC_E11630 Neighboring gene synaptogyrin 3 Neighboring gene NADPH oxidase organizer 1 Neighboring gene transducin (beta)-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E10937

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables flavin adenine dinucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin adenine dinucleotide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables flavin-dependent sulfhydryl oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables flavin-dependent sulfhydryl oxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to actinomycin D IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in liver regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in liver regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of natural killer cell mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    FAD-linked sulfhydryl oxidase ALR
    Names
    augmenter of liver regeneration
    growth factor, erv1-like (augmenter of liver regeneration)
    NP_001365967.1
    NP_001365968.1
    NP_001396906.1
    NP_001396910.1
    NP_075527.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001379038.1NP_001365967.1  FAD-linked sulfhydryl oxidase ALR isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154566, CJ043716
      UniProtKB/TrEMBL
      A0A3Q4EGL6
      Related
      ENSMUSP00000157249.2, ENSMUST00000234235.2
      Conserved Domains (1) summary
      pfam04777
      Location:87177
      Evr1_Alr; Erv1 / Alr family
    2. NM_001379039.1NP_001365968.1  FAD-linked sulfhydryl oxidase ALR isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC154566
      Conserved Domains (1) summary
      cl02107
      Location:79144
      Evr1_Alr; Erv1 / Alr family
    3. NM_001409977.1NP_001396906.1  FAD-linked sulfhydryl oxidase ALR isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC154566
    4. NM_001409981.1NP_001396910.1  FAD-linked sulfhydryl oxidase ALR isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC154566
    5. NM_023040.4NP_075527.2  FAD-linked sulfhydryl oxidase ALR isoform 1

      See identical proteins and their annotated locations for NP_075527.2

      Status: VALIDATED

      Source sequence(s)
      AC154566
      Consensus CDS
      CCDS28492.1
      UniProtKB/Swiss-Prot
      P56213, Q8CIF8, Q9JJE6
      Related
      ENSMUSP00000049186.9, ENSMUST00000046839.10
      Conserved Domains (1) summary
      cl02107
      Location:79194
      Evr1_Alr; Erv1 / Alr family

    RNA

    1. NR_176925.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154566
    2. NR_176926.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154566

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24912164..24915065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_212443.1: Suppressed sequence

      Description
      NM_212443.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.